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  • Lycopene's effects on cancer cell functions within monolayer and spheroid cultures

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    KaemmererPUB3119.pdf (307.9Kb)
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    Accepted Manuscript (AM)
    Author(s)
    Holzapfel, Nina Pauline
    Holzapfel, Boris Michael
    Theodoropoulos, Christina
    Kaemmerer, Elke
    Rausch, Tamara
    Feldthusen, Jesper
    Champ, Simon
    Clements, Judith Ann
    Hutmacher, Dietmar Werner
    Loessner, Daniela
    Griffith University Author(s)
    Kaemmerer, Elke
    Year published
    2016
    Metadata
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    Abstract
    Lycopene, a compound that blocks the action of free radicals and oxygen molecules, is found in tomatoes and tomato-based products and linked to a reduced incidence of cancer. Increasing willingness of patients to maintain a healthy lifestyle by supplemental intake of nutrients and acceptance of alternative therapeutics has boosted research into nutraceuticals. The potential of lycopene to prevent or treat cancer has been investigated, but outcomes are inconsistent and its mode of action is still unknown. Further studies are needed to understand the role of lycopene in cancer prevention and treatment. The impact of lycopene ...
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    Lycopene, a compound that blocks the action of free radicals and oxygen molecules, is found in tomatoes and tomato-based products and linked to a reduced incidence of cancer. Increasing willingness of patients to maintain a healthy lifestyle by supplemental intake of nutrients and acceptance of alternative therapeutics has boosted research into nutraceuticals. The potential of lycopene to prevent or treat cancer has been investigated, but outcomes are inconsistent and its mode of action is still unknown. Further studies are needed to understand the role of lycopene in cancer prevention and treatment. The impact of lycopene on viability, proliferation, migration, and invasion of five different cancer cell lines was determined using monolayer and spheroid cultures. Cell viability was significantly reduced upon lycopene treatment at physiologically attainable concentrations. Cell proliferation, migration, and invasion did not change upon lycopene treatment. Ovarian cancer spheroids initially showed a decreased proliferation and after 14 days increased cell viability upon lycopene treatment, confirming the potential of lycopene to reduce cancer cell growth in short-term cultures and also indicate enhanced cell viability over prolonged exposure. This study cannot substantiate that lycopene inhibits cell functions associated with tumor growth, even in a 3D cancer model that mimics the natural tumor microenvironment.
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    Journal Title
    Nutrition and Cancer
    Volume
    68
    Issue
    2
    DOI
    https://doi.org/10.1080/01635581.2016.1150498
    Copyright Statement
    © 2016 Taylor & Francis (Routledge). This is an Accepted Manuscript of an article published by Taylor & Francis in Nutrition and Cancer on 25 March 2016, available online: https://doi.org/10.1080/01635581.2016.1150498
    Subject
    Nutrition and dietetics
    Nutrition and dietetics not elsewhere classified
    Oncology and carcinogenesis
    Oncology and carcinogenesis not elsewhere classified
    Publication URI
    http://hdl.handle.net/10072/343837
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    • Journal articles

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