dc.contributor.author | Chelini, A | |
dc.contributor.author | Brogi, S | |
dc.contributor.author | Paolino, M | |
dc.contributor.author | Di Capua, A | |
dc.contributor.author | Cappelli, A | |
dc.contributor.author | Giorgi, G | |
dc.contributor.author | Farzad, M | |
dc.contributor.author | Di Cesare Mannelli, L | |
dc.contributor.author | Micheli, L | |
dc.contributor.author | Ghelardini, C | |
dc.contributor.author | Anzini, M | |
dc.date.accessioned | 2017-08-11T12:30:48Z | |
dc.date.available | 2017-08-11T12:30:48Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 0022-2623 | |
dc.identifier.doi | 10.1021/acs.jmedchem.7b00383 | |
dc.identifier.uri | http://hdl.handle.net/10072/343840 | |
dc.description.abstract | LDN-212320 (3) was found to be a potent EAAT2 activator at a translational level, restoring the normal clearance of glutamate and providing neuronal protection. Since the pharmacologic activation of EAAT2 represents a valuable strategy to relieve neuropathic pain, we synthesized novel activators (4a–f) of EAAT2. Among them 4f, analyzed in comparison with 3 by different paradigms in a rat model of oxaliplatin-induced neuropathic pain, showed the better antihypersensitive profile being able to fully counteract the oxaliplatin-induced neuropathy. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | American Chemical Society | |
dc.relation.ispartofpagefrom | 5216 | |
dc.relation.ispartofpageto | 5221 | |
dc.relation.ispartofissue | 12 | |
dc.relation.ispartofjournal | Journal of Medicinal Chemistry | |
dc.relation.ispartofvolume | 60 | |
dc.subject.fieldofresearch | Medicinal and biomolecular chemistry | |
dc.subject.fieldofresearch | Medicinal and biomolecular chemistry not elsewhere classified | |
dc.subject.fieldofresearch | Organic chemistry | |
dc.subject.fieldofresearch | Pharmacology and pharmaceutical sciences | |
dc.subject.fieldofresearchcode | 3404 | |
dc.subject.fieldofresearchcode | 340499 | |
dc.subject.fieldofresearchcode | 3405 | |
dc.subject.fieldofresearchcode | 3214 | |
dc.title | Synthesis and Biological Evaluation of Novel Neuroprotective Pyridazine Derivatives as Excitatory Amino Acid Transporter 2 (EAAT2) Activators | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Di Capua, Angela | |