Show simple item record

dc.contributor.authorChelini, A
dc.contributor.authorBrogi, S
dc.contributor.authorPaolino, M
dc.contributor.authorDi Capua, A
dc.contributor.authorCappelli, A
dc.contributor.authorGiorgi, G
dc.contributor.authorFarzad, M
dc.contributor.authorDi Cesare Mannelli, L
dc.contributor.authorMicheli, L
dc.contributor.authorGhelardini, C
dc.contributor.authorAnzini, M
dc.date.accessioned2017-08-11T12:30:48Z
dc.date.available2017-08-11T12:30:48Z
dc.date.issued2017
dc.identifier.issn0022-2623
dc.identifier.doi10.1021/acs.jmedchem.7b00383
dc.identifier.urihttp://hdl.handle.net/10072/343840
dc.description.abstractLDN-212320 (3) was found to be a potent EAAT2 activator at a translational level, restoring the normal clearance of glutamate and providing neuronal protection. Since the pharmacologic activation of EAAT2 represents a valuable strategy to relieve neuropathic pain, we synthesized novel activators (4a–f) of EAAT2. Among them 4f, analyzed in comparison with 3 by different paradigms in a rat model of oxaliplatin-induced neuropathic pain, showed the better antihypersensitive profile being able to fully counteract the oxaliplatin-induced neuropathy.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.relation.ispartofpagefrom5216
dc.relation.ispartofpageto5221
dc.relation.ispartofissue12
dc.relation.ispartofjournalJournal of Medicinal Chemistry
dc.relation.ispartofvolume60
dc.subject.fieldofresearchMedicinal and biomolecular chemistry
dc.subject.fieldofresearchMedicinal and biomolecular chemistry not elsewhere classified
dc.subject.fieldofresearchOrganic chemistry
dc.subject.fieldofresearchPharmacology and pharmaceutical sciences
dc.subject.fieldofresearchcode3404
dc.subject.fieldofresearchcode340499
dc.subject.fieldofresearchcode3405
dc.subject.fieldofresearchcode3214
dc.titleSynthesis and Biological Evaluation of Novel Neuroprotective Pyridazine Derivatives as Excitatory Amino Acid Transporter 2 (EAAT2) Activators
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorDi Capua, Angela


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record