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Enhancing the pharmacodynamic profile of a class of selective COX-2 inhibiting nitric oxide donors

dc.contributor.authorBiava, M
dc.contributor.authorBattilocchio, C
dc.contributor.authorPoce, G
dc.contributor.authorAlfonso, S
dc.contributor.authorConsalvi, S
dc.contributor.authorDi Capua, A
dc.contributor.authorCalderone, V
dc.contributor.authorMartelli, A
dc.contributor.authorTestai, L
dc.contributor.authorSautebin, L
dc.contributor.authorRossi, A
dc.contributor.authorGhelardini, C
dc.contributor.authorDi Cesare Mannelli, L
dc.contributor.authorGiordani, A
dc.contributor.authorPersiani, S
dc.contributor.authorColovic, M
dc.contributor.authorDovizio, M
dc.contributor.authorPatrignani, P
dc.contributor.authorAnzini, M
dc.date.accessioned2017-08-11T12:30:47Z
dc.date.available2017-08-11T12:30:47Z
dc.date.issued2014
dc.identifier.issn0968-0896
dc.identifier.doi10.1016/j.bmc.2013.12.008
dc.identifier.urihttp://hdl.handle.net/10072/343849
dc.description.abstractWe report herein the development, synthesis, physicochemical and pharmacological characterization of a novel class of pharmacodynamic hybrids that selectively inhibit cyclooxygenase-2 (COX-2) isoform and present suitable nitric oxide releasing properties. The replacement of the ester moiety with the amide group gave access to in vivo more stable and active derivatives that highlighted outstanding pharmacological properties. In particular, the glycine derivative proved to be extremely active in suppressing hyperalgesia and edema.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofpagefrom772
dc.relation.ispartofpageto786
dc.relation.ispartofissue2
dc.relation.ispartofjournalBioorganic and Medicinal Chemistry
dc.relation.ispartofvolume22
dc.subject.fieldofresearchMedicinal and biomolecular chemistry
dc.subject.fieldofresearchMedicinal and biomolecular chemistry not elsewhere classified
dc.subject.fieldofresearchOrganic chemistry
dc.subject.fieldofresearchPharmacology and pharmaceutical sciences
dc.subject.fieldofresearchcode3404
dc.subject.fieldofresearchcode340499
dc.subject.fieldofresearchcode3405
dc.subject.fieldofresearchcode3214
dc.titleEnhancing the pharmacodynamic profile of a class of selective COX-2 inhibiting nitric oxide donors
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorDi Capua, Angela


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