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dc.contributor.authorEskandari, Sharareh
dc.contributor.authorVarshosaz, Jaleh
dc.contributor.authorMinaiyan, Mohsen
dc.contributor.authorTabbakhian, Majid
dc.date.accessioned2017-08-11T05:01:05Z
dc.date.available2017-08-11T05:01:05Z
dc.date.issued2011
dc.identifier.issn1178-2013
dc.identifier.doi10.2147/IJN.S15881
dc.identifier.urihttp://hdl.handle.net/10072/343856
dc.description.abstractThe treatment of brain disorders is one of the greatest challenges in drug delivery because of a variety of main barriers in effective drug transport and maintaining therapeutic concentrations in the brain for a prolonged period. The objective of this study was delivery of valproic acid (VPA) to the brain by intranasal route. For this purpose, nanostructured lipid carriers (NLCs) were prepared by solvent diffusion method followed by ultrasonication and characterized for size, zeta potential, drug-loading percentage, and release. Six groups of rats each containing six animals received drug-loaded NLCs intraperitoneally (IP) or intranasally. Brain responses were then examined by using maximal electroshock (MES). The hind limb tonic extension:flexion inhibition ratio was measured at 15-, 30-, 60-, 90-, and 120-minute intervals. The drug concentration was also measured in plasma and brain at the most protective point using gas chromatography method. The particle size of NLCs was 154 ± 16 nm with drug-loading percentage of 47% ± 0.8% and drug release of 75% ± 1.9% after 21 days. In vivo results showed that there was a significant difference between protective effects of NLCs of VPA and control group 15, 30, 60, and 90 minutes after treatment via intranasal route (P < 0.05). Similar protective effect was observed in rats treated with NLCs of VPA in intranasal route and positive control in IP route (P > 0.05). Results of drug determination in brain and plasma showed that brain:plasma concentration ratio was much higher after intranasal administration of NLCs of VPA than the positive control group (IP route). In conclusion, intranasal administration of NLCs of VPA provided a better protection against MES seizure.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherDove Medical Press
dc.relation.ispartofpagefrom363
dc.relation.ispartofpageto371
dc.relation.ispartofjournalInternational Journal of Nanomedicine
dc.relation.ispartofvolume6
dc.subject.fieldofresearchPharmacology and Pharmaceutical Sciences not elsewhere classified
dc.subject.fieldofresearchNanotechnology not elsewhere classified
dc.subject.fieldofresearchBiochemistry and Cell Biology
dc.subject.fieldofresearchNanotechnology
dc.subject.fieldofresearchPharmacology and Pharmaceutical Sciences
dc.subject.fieldofresearchcode111599
dc.subject.fieldofresearchcode100799
dc.subject.fieldofresearchcode0601
dc.subject.fieldofresearchcode1007
dc.subject.fieldofresearchcode1115
dc.titleBrain delivery of valproic acid via intranasal administration of nanostructured lipid carriers: in vivo pharmacodynamic studies using rat electroshock model
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttps://creativecommons.org/licenses/by-nc/3.0/
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2011 Eskandari et al, publisher and licensee Dove Medical Press Ltd. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.
gro.hasfulltextFull Text
gro.griffith.authorEskandari, Sharareh


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