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dc.contributor.authorVarshosaz, Jaleh
dc.contributor.authorEskandari, Sharareh
dc.contributor.authorTabbakhian, Majid
dc.date.accessioned2017-08-11T05:02:05Z
dc.date.available2017-08-11T05:02:05Z
dc.date.issued2012
dc.identifier.issn0144-8617
dc.identifier.doi10.1016/j.carbpol.2012.01.051
dc.identifier.urihttp://hdl.handle.net/10072/343857
dc.description.abstractFreeze-drying technique preserves the stability of nanoparticles. The objective of this study was optimization of freeze-drying condition of nano lipid carriers (NLCs). NLCs were prepared by emulsion-solvent evaporation followed by ultra-sonication method. Different carbohydrate and polymeric cryoprotectants including Microcelac® (mixture of lactose and Avicel), Avicel PH102 (microcrystalline cellulose), mannitol, sucrose, Avicel RC591 (mixture of microcrystalline cellulose and sodium carboxymethyl cellulose), maltodextrine, Aerosil and PEG4000 were tested initially. The NLCs showing lower particle size growth and greater absolute zeta potential after freeze drying were chosen for further investigation using Taguchi optimization method. Studied factors included cryoprotectant type and concentration, freezing temperatures applied at different time periods and sublimation time. Sucrose, Avicel RC591 and Aerosil were selected as cryoprotectants from initial screening tests. Increasing their concentration increased the particle size. 1% of Avicel RC591, 24 h of freezing at −70 °C and 48 h sublimation time showed lower growth in particle size.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherPergamon Press
dc.relation.ispartofpagefrom1157
dc.relation.ispartofpageto1163
dc.relation.ispartofissue4
dc.relation.ispartofjournalCarbohydrate Polymers
dc.relation.ispartofvolume88
dc.subject.fieldofresearchOrganic Chemistry not elsewhere classified
dc.subject.fieldofresearchMacromolecular and Materials Chemistry
dc.subject.fieldofresearchOrganic Chemistry
dc.subject.fieldofresearchFood Sciences
dc.subject.fieldofresearchcode030599
dc.subject.fieldofresearchcode0303
dc.subject.fieldofresearchcode0305
dc.subject.fieldofresearchcode0908
dc.titleFreeze-drying of nanostructure lipid carriers by different carbohydrate polymers used as cryoprotectants
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorEskandari, Sharareh


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