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  • Factors affecting the production of nanostructure lipid carriers of valproic acid

    Author(s)
    Varshosaz, Jaleh
    Eskandari, Sharareh
    Kennedy, Ross
    Tabbakhian, Majid
    Minaiyan, Mohsen
    Griffith University Author(s)
    Eskandari, Sherry
    Year published
    2013
    Metadata
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    Abstract
    The objective of this study was to optimize a nano-lipid carrier (NLCs) of valproic acid for nasal delivery using statistical methods. NLCs were prepared by solvent diffusion method followed by ultrasonication. After a preliminary screening study using Taguchi design, the Box-Behnken statistical model using desirability function was applied to evaluate variables affecting key specifications (minimum particle size, maximum drug loading and optimum release) of nano-lipid carriers of valproic acid. Each variable was assessed at three levels of surfactant concentration, acetone/ethanol volume ratio and organic/aqueous phase ...
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    The objective of this study was to optimize a nano-lipid carrier (NLCs) of valproic acid for nasal delivery using statistical methods. NLCs were prepared by solvent diffusion method followed by ultrasonication. After a preliminary screening study using Taguchi design, the Box-Behnken statistical model using desirability function was applied to evaluate variables affecting key specifications (minimum particle size, maximum drug loading and optimum release) of nano-lipid carriers of valproic acid. Each variable was assessed at three levels of surfactant concentration, acetone/ethanol volume ratio and organic/aqueous phase volume ratio. The best predicted model for particle size and drug release was quadratic model, while for drug loading, 2 factor interaction model fitted better. The measured results for the optimized formulation were a mean size of 154 nm, 47% payload and 75% of drug content released within 21 days. The optimum formulation was obtained using 1% of Poloxamer-188 as surfactant, organic/aqueous phase volume ratio of 1/5 and acetone/ethanol volume ratio of 3/1. Overall, the results show that entrapment of valproic acid in nano-lipid carriers was achieved. Such carriers might be a promising delivery system in the treatment of seizures via the nasal route of administration.
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    Journal Title
    Journal of Biomedical Nanotechnology
    Volume
    9
    Issue
    2
    DOI
    https://doi.org/10.1166/jbn.2013.1484
    Copyright Statement
    Self-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the author[s] for more information.
    Subject
    Inorganic chemistry
    Materials engineering
    Nanotechnology
    Nanotechnology not elsewhere classified
    Publication URI
    http://hdl.handle.net/10072/343858
    Collection
    • Journal articles

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