Show simple item record

dc.contributor.authorVarshosaz, Jaleh
dc.contributor.authorEskandari, Sharareh
dc.contributor.authorKennedy, Ross
dc.contributor.authorTabbakhian, Majid
dc.contributor.authorMinaiyan, Mohsen
dc.description.abstractThe objective of this study was to optimize a nano-lipid carrier (NLCs) of valproic acid for nasal delivery using statistical methods. NLCs were prepared by solvent diffusion method followed by ultrasonication. After a preliminary screening study using Taguchi design, the Box-Behnken statistical model using desirability function was applied to evaluate variables affecting key specifications (minimum particle size, maximum drug loading and optimum release) of nano-lipid carriers of valproic acid. Each variable was assessed at three levels of surfactant concentration, acetone/ethanol volume ratio and organic/aqueous phase volume ratio. The best predicted model for particle size and drug release was quadratic model, while for drug loading, 2 factor interaction model fitted better. The measured results for the optimized formulation were a mean size of 154 nm, 47% payload and 75% of drug content released within 21 days. The optimum formulation was obtained using 1% of Poloxamer-188 as surfactant, organic/aqueous phase volume ratio of 1/5 and acetone/ethanol volume ratio of 3/1. Overall, the results show that entrapment of valproic acid in nano-lipid carriers was achieved. Such carriers might be a promising delivery system in the treatment of seizures via the nasal route of administration.
dc.publisherAmerican Scientific Publishers
dc.relation.ispartofjournalJournal of Biomedical Nanotechnology
dc.subject.fieldofresearchNanotechnology not elsewhere classified
dc.subject.fieldofresearchInorganic Chemistry
dc.subject.fieldofresearchMaterials Engineering
dc.titleFactors affecting the production of nanostructure lipid carriers of valproic acid
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyrightSelf-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the author[s] for more information.
gro.hasfulltextNo Full Text
gro.griffith.authorEskandari, Sharareh

Files in this item


There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record