dc.contributor.author | Eskandari, Sharareh | |
dc.contributor.author | Varamini, Pegah | |
dc.contributor.author | Toth, Istvan | |
dc.date.accessioned | 2017-08-11T05:04:34Z | |
dc.date.available | 2017-08-11T05:04:34Z | |
dc.date.issued | 2013 | |
dc.identifier.issn | 0898-2104 | |
dc.identifier.doi | 10.3109/08982104.2013.805339 | |
dc.identifier.uri | http://hdl.handle.net/10072/343859 | |
dc.description.abstract | Three different formulations of a lipid-modified endomorphin-1 peptide (C10LAA-Endo-1) were prepared, characterized, and evaluated for their permeability through Caco-2 cell membranes. Solid lipid nanoparticles (SLN), enteric coated (EC), and the EC-SLN of C10LAA-Endo-1 is a modified structure of endomorphin-1 for oral delivery. Physico–chemical characterization of the formulations showed that among all formulations, EC-[C10LAA-Endo-1] had the lowest particle size and the highest EE% and absolute zeta potential. Release of drug from SLN, EC-SLN and EC-[C10LAA-Endo-1] in acid media was 14.30 (±2.7)%, 3.0 (±1.0)% and 10.2 (±3.0)%, respectively. Release data in buffer media (pH = 7.4) showed that enteric coated formulations released C10LAA-Endo-1 more slowly than uncoated formulations. It was also demonstrated that direct coating of C10LAA-Endo-1 with Eudragit® S100 significantly enhanced the permeability of the compound through Caco-2 cell membranes with a 39-fold higher Papp compared to C10LAA-Endo-1. These findings indicated that EC-C10LAA-Endo-1 is a promising candidate to promote the oral delivery of the previously modified endomorphin-1 peptide analogue and is worthy of future animal investigations. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Taylor and Francis Inc | |
dc.relation.ispartofpagefrom | 311 | |
dc.relation.ispartofpageto | 317 | |
dc.relation.ispartofissue | 4 | |
dc.relation.ispartofjournal | Journal of Liposome Research | |
dc.relation.ispartofvolume | 23 | |
dc.subject.fieldofresearch | Pharmacology and pharmaceutical sciences | |
dc.subject.fieldofresearch | Pharmacology and pharmaceutical sciences not elsewhere classified | |
dc.subject.fieldofresearchcode | 3214 | |
dc.subject.fieldofresearchcode | 321499 | |
dc.title | Formulation, characterization and permeability study of nano particles of lipo-endomorphin-1 for oral delivery | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Eskandari, Sherry | |