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dc.contributor.authorEskandari, Sharareh
dc.contributor.authorVaramini, Pegah
dc.contributor.authorToth, Istvan
dc.date.accessioned2017-08-11T05:04:34Z
dc.date.available2017-08-11T05:04:34Z
dc.date.issued2013
dc.identifier.issn0898-2104
dc.identifier.doi10.3109/08982104.2013.805339
dc.identifier.urihttp://hdl.handle.net/10072/343859
dc.description.abstractThree different formulations of a lipid-modified endomorphin-1 peptide (C10LAA-Endo-1) were prepared, characterized, and evaluated for their permeability through Caco-2 cell membranes. Solid lipid nanoparticles (SLN), enteric coated (EC), and the EC-SLN of C10LAA-Endo-1 is a modified structure of endomorphin-1 for oral delivery. Physico–chemical characterization of the formulations showed that among all formulations, EC-[C10LAA-Endo-1] had the lowest particle size and the highest EE% and absolute zeta potential. Release of drug from SLN, EC-SLN and EC-[C10LAA-Endo-1] in acid media was 14.30 (±2.7)%, 3.0 (±1.0)% and 10.2 (±3.0)%, respectively. Release data in buffer media (pH = 7.4) showed that enteric coated formulations released C10LAA-Endo-1 more slowly than uncoated formulations. It was also demonstrated that direct coating of C10LAA-Endo-1 with Eudragit® S100 significantly enhanced the permeability of the compound through Caco-2 cell membranes with a 39-fold higher Papp compared to C10LAA-Endo-1. These findings indicated that EC-C10LAA-Endo-1 is a promising candidate to promote the oral delivery of the previously modified endomorphin-1 peptide analogue and is worthy of future animal investigations.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherTaylor and Francis Inc
dc.relation.ispartofpagefrom311
dc.relation.ispartofpageto317
dc.relation.ispartofissue4
dc.relation.ispartofjournalJournal of Liposome Research
dc.relation.ispartofvolume23
dc.subject.fieldofresearchPharmacology and pharmaceutical sciences
dc.subject.fieldofresearchPharmacology and pharmaceutical sciences not elsewhere classified
dc.subject.fieldofresearchcode3214
dc.subject.fieldofresearchcode321499
dc.titleFormulation, characterization and permeability study of nano particles of lipo-endomorphin-1 for oral delivery
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorEskandari, Sherry


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