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dc.contributor.authorKamal, Ahmed
dc.contributor.authorMallareddy, Adla
dc.contributor.authorRamaiah, M. Janaki
dc.contributor.authorPushpavalli, Sreerangam N.C.V.L.
dc.contributor.authorSuresh, Paidakula
dc.contributor.authorKishor, Chandan
dc.contributor.authorMurty, J. NSRC
dc.contributor.authorRao, N. Sankara
dc.contributor.authorGhosh, Sowjanya
dc.contributor.authorAddlagatta, Anthony
dc.contributor.authorPal-Bhadra, Manika
dc.date.accessioned2017-08-14T12:31:16Z
dc.date.available2017-08-14T12:31:16Z
dc.date.issued2012
dc.identifier.issn0223-5234
dc.identifier.doi10.1016/j.ejmech.2012.08.021
dc.identifier.urihttp://hdl.handle.net/10072/343945
dc.description.abstractA series of combretastatin-amidobenzothiazole conjugates have been synthesized and evaluated for their anticancer activity. All these compounds exhibited significant anticancer activity and the most potent compound (11a) showed GI50 values ranging 0.019–11 μM. Biological studies such as cell cycle distribution, effect on tubulin polymerization and effect on ERK signalling pathway have been examined in MCF-7 cell line. FACS analysis revealed that these compounds induced cell cycle arrest at G2/M phase. Compound 11a showed significant effect on tubulin polymerization and affected the ERK signalling pathway that result in the decreased levels of ERK1/2, p-ERK and c-Jun proteins. Docking experiments have shown that the active molecules interact and bind well in the ATP binding pocket of ERK protein.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofpagefrom166
dc.relation.ispartofpageto178
dc.relation.ispartofjournalEuropean Journal of Medicinal Chemistry
dc.relation.ispartofvolume56
dc.subject.fieldofresearchMedicinal and Biomolecular Chemistry not elsewhere classified
dc.subject.fieldofresearchMedicinal and Biomolecular Chemistry
dc.subject.fieldofresearchOrganic Chemistry
dc.subject.fieldofresearchPharmacology and Pharmaceutical Sciences
dc.subject.fieldofresearchcode030499
dc.subject.fieldofresearchcode0304
dc.subject.fieldofresearchcode0305
dc.subject.fieldofresearchcode1115
dc.titleSynthesis and biological evaluation of combretastatin-amidobenzothiazole conjugates as potential anticancer agents
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorKishor, Chandan


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