dc.contributor.author | Consalvi, S | |
dc.contributor.author | Alfonso, S | |
dc.contributor.author | Di Capua, A | |
dc.contributor.author | Poce, G | |
dc.contributor.author | Pirolli, A | |
dc.contributor.author | Sabatino, M | |
dc.contributor.author | Ragno, R | |
dc.contributor.author | Anzini, M | |
dc.contributor.author | Sartini, S | |
dc.contributor.author | La Motta, C | |
dc.contributor.author | Di Cesare Mannelli, L | |
dc.contributor.author | Ghelardini, C | |
dc.contributor.author | Biava, M | |
dc.date.accessioned | 2017-08-14T03:24:41Z | |
dc.date.available | 2017-08-14T03:24:41Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 0968-0896 | |
dc.identifier.doi | 10.1016/j.bmc.2014.12.041 | |
dc.identifier.uri | http://hdl.handle.net/10072/343962 | |
dc.description.abstract | We report herein the synthesis, biological evaluation and docking analysis of a new series of methylsulfonyl, sulfamoyl acetamides and ethyl acetates that selectively inhibit cyclooxygenase-2 (COX-2) isoform. Among the newly synthesized compounds, some of them were endowed with a good activity against COX-2 and a good selectivity COX-2/COX-1 in vitro as well as a desirable analgesic activity in vivo, proving that replacement of the ester moiety with an amide group gave access to more stable derivatives, characterized by a good COX-inhibition. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Elsevier | |
dc.relation.ispartofpagefrom | 810 | |
dc.relation.ispartofpageto | 820 | |
dc.relation.ispartofissue | 4 | |
dc.relation.ispartofjournal | Bioorganic and Medicinal Chemistry | |
dc.relation.ispartofvolume | 23 | |
dc.subject.fieldofresearch | Medicinal and biomolecular chemistry | |
dc.subject.fieldofresearch | Medicinal and biomolecular chemistry not elsewhere classified | |
dc.subject.fieldofresearch | Organic chemistry | |
dc.subject.fieldofresearch | Pharmacology and pharmaceutical sciences | |
dc.subject.fieldofresearchcode | 3404 | |
dc.subject.fieldofresearchcode | 340499 | |
dc.subject.fieldofresearchcode | 3405 | |
dc.subject.fieldofresearchcode | 3214 | |
dc.title | Synthesis, biological evaluation and docking analysis of a new series of methylsulfonyl and sulfamoyl acetamides and ethyl acetates as potent COX-2 inhibitors | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Di Capua, Angela | |