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dc.contributor.authorConsalvi, S
dc.contributor.authorAlfonso, S
dc.contributor.authorDi Capua, A
dc.contributor.authorPoce, G
dc.contributor.authorPirolli, A
dc.contributor.authorSabatino, M
dc.contributor.authorRagno, R
dc.contributor.authorAnzini, M
dc.contributor.authorSartini, S
dc.contributor.authorLa Motta, C
dc.contributor.authorDi Cesare Mannelli, L
dc.contributor.authorGhelardini, C
dc.contributor.authorBiava, M
dc.date.accessioned2017-08-14T03:24:41Z
dc.date.available2017-08-14T03:24:41Z
dc.date.issued2015
dc.identifier.issn0968-0896
dc.identifier.doi10.1016/j.bmc.2014.12.041
dc.identifier.urihttp://hdl.handle.net/10072/343962
dc.description.abstractWe report herein the synthesis, biological evaluation and docking analysis of a new series of methylsulfonyl, sulfamoyl acetamides and ethyl acetates that selectively inhibit cyclooxygenase-2 (COX-2) isoform. Among the newly synthesized compounds, some of them were endowed with a good activity against COX-2 and a good selectivity COX-2/COX-1 in vitro as well as a desirable analgesic activity in vivo, proving that replacement of the ester moiety with an amide group gave access to more stable derivatives, characterized by a good COX-inhibition.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofpagefrom810
dc.relation.ispartofpageto820
dc.relation.ispartofissue4
dc.relation.ispartofjournalBioorganic and Medicinal Chemistry
dc.relation.ispartofvolume23
dc.subject.fieldofresearchMedicinal and biomolecular chemistry
dc.subject.fieldofresearchMedicinal and biomolecular chemistry not elsewhere classified
dc.subject.fieldofresearchOrganic chemistry
dc.subject.fieldofresearchPharmacology and pharmaceutical sciences
dc.subject.fieldofresearchcode3404
dc.subject.fieldofresearchcode340499
dc.subject.fieldofresearchcode3405
dc.subject.fieldofresearchcode3214
dc.titleSynthesis, biological evaluation and docking analysis of a new series of methylsulfonyl and sulfamoyl acetamides and ethyl acetates as potent COX-2 inhibitors
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorDi Capua, Angela


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