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dc.contributor.authorWinearls, James
dc.contributor.authorCampbell, Don
dc.contributor.authorHurn, Catherine
dc.contributor.authorFuryk, Jeremy
dc.contributor.authorRyan, Glenn
dc.contributor.authorTrout, Melita
dc.contributor.authorWalsham, James
dc.contributor.authorHolley, Anthony
dc.contributor.authorShuttleworth, Megan
dc.contributor.authorDyer, Wayne
dc.contributor.authorKeijzers, Gerben
dc.contributor.authorPresneill, Jeff
dc.contributor.authorFraser, John F
dc.contributor.authorWullschleger, Martin
dc.date.accessioned2017-08-14T04:36:09Z
dc.date.available2017-08-14T04:36:09Z
dc.date.issued2017
dc.identifier.issn0020-1383
dc.identifier.doi10.1016/j.injury.2016.12.012
dc.identifier.urihttp://hdl.handle.net/10072/343985
dc.description.abstractHaemorrhage in the setting of severe trauma is associated with significant morbidity and mortality. There is increasing awareness of the important role fibrinogen plays in traumatic haemorrhage. Fibrinogen levels fall precipitously in severe trauma and the resultant hypofibrinogenaemia is associated with poor outcomes. Hence, it has been postulated that early fibrinogen replacement in severe traumatic haemorrhage may improve outcomes, although, to date there is a paucity of high quality evidence to support this hypothesis. In addition there is controversy regarding the optimal method for fibrinogen supplementation. We review the current evidence regarding the role of fibrinogen in trauma, the rationale behind fibrinogen supplementation and discuss current research.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherElsevier
dc.relation.ispartofpagefrom230
dc.relation.ispartofpageto242
dc.relation.ispartofissue2
dc.relation.ispartofjournalInjury
dc.relation.ispartofvolume48
dc.subject.fieldofresearchPublic Health and Health Services not elsewhere classified
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchNursing
dc.subject.fieldofresearchPublic Health and Health Services
dc.subject.fieldofresearchcode111799
dc.subject.fieldofresearchcode1103
dc.subject.fieldofresearchcode1110
dc.subject.fieldofresearchcode1117
dc.titleFibrinogen in traumatic haemorrhage: A narrative review
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Medical Science
gro.hasfulltextNo Full Text
gro.griffith.authorKeijzers, Gerben
gro.griffith.authorShuttleworth, Megan R.
gro.griffith.authorWinearls, James
gro.griffith.authorWullschleger, Martin
gro.griffith.authorFraser, John F.
gro.griffith.authorCampbell, Donald G.


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