Show simple item record

dc.contributor.authorAbrantes, Joanaen_US
dc.contributor.authorPosada, Daviden_US
dc.contributor.authorGuillon, Patriceen_US
dc.contributor.authorJ. Esteves, Pedroen_US
dc.contributor.authorPendu, Jacquesen_US
dc.date.accessioned2017-04-24T13:09:59Z
dc.date.available2017-04-24T13:09:59Z
dc.date.issued2009en_US
dc.date.modified2010-10-06T06:55:11Z
dc.identifier.issn00222844en_US
dc.identifier.doi10.1007/s00239-009-9239-0en_AU
dc.identifier.urihttp://hdl.handle.net/10072/34401
dc.description.abstractThe alpha-2-fucosyltransferases (alpha2FTs) are enzymes involved in the biosynthesis of alpha2fucosylated glycan structures. In mammalian genomes, there are three alpha2FT genes located in tandem-FUT1, FUT2, and Sec1-each contained within a single exon. It has been suggested that these genes originated from two successive duplications, with FUT1 being generated first and FUT2 and Sec1 second. Despite gene conversion being considered the main mechanism of concerted evolution in gene families, previous studies of primates alpha2FTs failed to detect it, although the occurrence of gene conversion between FUT2 and Sec1 was recently reported in a human allele. The primary aim of our work was to initiate a broader study on the molecular evolution of mammalian alpha2FTs. Sequence comparison leads us to confirm that the three genes appeared by two rounds of duplication. In addition, we were able to detect multiple gene-conversion events at the base of primates and within several nonprimate species involving FUT2 and Sec1. Gene conversion involving FUT1 and either FUT2 or Sec1 was also detected in rabbit. The extent of gene conversion between the alpha2FTs genes appears to be species-specific, possibly related to functional differentiation of these genes. With the exception of rabbits, gene conversion was not observed in the region coding the C-terminal part of the catalytic domain. In this region, the number of amino acids that are identical between FUT1 and FUT2, but different in Sec1, is higher than in other parts of the protein. The biologic meaning of this observation may be related to functional constraints.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherSpringer-Verlagen_US
dc.publisher.placeBerlin, Germanyen_US
dc.relation.ispartofstudentpublicationYen_AU
dc.relation.ispartofpagefrom22en_US
dc.relation.ispartofpageto31en_US
dc.relation.ispartofissue1en_US
dc.relation.ispartofjournalJournal of molecular evolutionen_US
dc.relation.ispartofvolume69en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchHost-Parasite Interactionsen_US
dc.subject.fieldofresearchcode060307en_US
dc.titleWidespread gene conversion of alpha-2-fucosyltransferase genes in mammalsen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2009
gro.hasfulltextNo Full Text


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record