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dc.contributor.authorAvgan, Nesli
dc.contributor.authorSutherland, Heidi G
dc.contributor.authorSpriggens, Lauren K
dc.contributor.authorYu, Chieh
dc.contributor.authorIbrahim, Omar
dc.contributor.authorBellis, Claire
dc.contributor.authorHaupt, Larisa M
dc.contributor.authorShum, David HK
dc.contributor.authorGriffiths, Lyn R
dc.date.accessioned2017-08-17T03:57:05Z
dc.date.available2017-08-17T03:57:05Z
dc.date.issued2017
dc.identifier.issn1422-0067
dc.identifier.doi10.3390/ijms18030655
dc.identifier.urihttp://hdl.handle.net/10072/344387
dc.description.abstractBrain-derived neurotrophic factor (BDNF) is involved in numerous cognitive functions including learning and memory. BDNF plays an important role in synaptic plasticity in humans and rats with BDNF shown to be essential for the formation of long-term memories. We previously identified a significant association between the BDNF Val66Met polymorphism (rs6265) and long-term visual memory (p-value = 0.003) in a small cohort (n = 181) comprised of healthy individuals who had been phenotyped for various aspects of memory function. In this study, we have extended the cohort to 597 individuals and examined multiple genetic variants across both the BDNF and BDNF-AS genes for association with visual memory performance as assessed by the Wechsler Memory Scale—Fourth Edition subtests Visual Reproduction I and II (VR I and II). VR I assesses immediate visual memory, whereas VR II assesses long-term visual memory. Genetic association analyses were performed for 34 single nucleotide polymorphisms genotyped on Illumina OmniExpress BeadChip arrays with the immediate and long-term visual memory phenotypes. While none of the BDNF and BDNF-AS variants were shown to be significant for immediate visual memory, we found 10 variants (including the Val66Met polymorphism (p-value = 0.006)) that were nominally associated, and three variants (two variants in BDNF and one variant in the BDNF-AS locus) that were significantly associated with long-term visual memory. Our data therefore suggests a potential role for BDNF, and its anti-sense transcript BDNF-AS, in long-term visual memory performance.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherMDPI
dc.relation.ispartofpagefrom655-1
dc.relation.ispartofpageto655-14
dc.relation.ispartofissue3
dc.relation.ispartofjournalInternational Journal of Molecular Sciences
dc.relation.ispartofvolume18
dc.subject.fieldofresearchGenetics not elsewhere classified
dc.subject.fieldofresearchOther Chemical Sciences
dc.subject.fieldofresearchGenetics
dc.subject.fieldofresearchOther Biological Sciences
dc.subject.fieldofresearchcode060499
dc.subject.fieldofresearchcode0399
dc.subject.fieldofresearchcode0604
dc.subject.fieldofresearchcode0699
dc.titleBDNF variants may modulate long-term visual memory performance in a healthy cohort
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2017 The Author(s). Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY 4.0) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorShum, David
gro.griffith.authorSpriggens, Lauren


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