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  • Effect of GPR84 deletion on obesity and diabetes development in mice fed long chain or medium chain fatty acid rich diets

    Author(s)
    Du Toit, Eugene
    Browne, Liam
    Irving-Rodgers, Helen
    Massa, Helen M
    Fozzard, Nicolette
    Jennings, Michael P
    Peak, Ian R
    Griffith University Author(s)
    Jennings, Michael P.
    Peak, Ian
    Massa, Helen M.
    Fozzard, Nikki
    Du Toit, Eugene
    Browne, Liam
    Irving-Rodgers, Helen F.
    Year published
    2018
    Metadata
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    Abstract
    Purpose: Although there is good evidence showing that diets rich in medium chain fatty acids (MCFAs) have less marked obesogenic and diabetogenic effects than diets rich in long chain fatty acids (LCFAs), the role of the pro-inflammatory, medium chain fatty acid receptor (GPR84) in the aetiology of obesity and glucose intolerance is not well characterised. We set out to determine whether GPR84 expression influences obesity and glucose intolerance susceptibility in MCFA and LCFA rich diet fed mice. Methods: Wild type (WT) and GPR84 knockout (KO) mice were fed a control, MCFA or LCFA diet, and body mass, heart, liver and ...
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    Purpose: Although there is good evidence showing that diets rich in medium chain fatty acids (MCFAs) have less marked obesogenic and diabetogenic effects than diets rich in long chain fatty acids (LCFAs), the role of the pro-inflammatory, medium chain fatty acid receptor (GPR84) in the aetiology of obesity and glucose intolerance is not well characterised. We set out to determine whether GPR84 expression influences obesity and glucose intolerance susceptibility in MCFA and LCFA rich diet fed mice. Methods: Wild type (WT) and GPR84 knockout (KO) mice were fed a control, MCFA or LCFA diet, and body mass, heart, liver and epididymal fat mass was assessed, as well as glucose tolerance and adipocyte size. Results: LCFA diets increased body mass and decreased glucose tolerance in both WT and GPR84 KO animals while MCFA diets had no effect on these parameters. There were no differences in body weight when comparing WT and GPR84 KO mice on the respective diets. Glucose tolerance was also similar in WT and GPR84 KO mice irrespective of diet. Liver mass was increased following LCFA feeding in WT but not GPR84 KO mice. Hepatic triglyceride content was increased in GPR84 KO animals fed MCFA, and myocardial triglyceride content was increased in GPR84 KO animals fed LCFA. Conclusions: GPR84 deletion had no effects on body weight or glucose tolerance in mice fed either a high MCFA or LCFA diet. GPR84 may influence lipid metabolism, as GPR84 KO mice had smaller livers and increased myocardial triglyceride accumulation when fed LCFA diets, and increased liver triglyceride accumulation in responses to increased dietary MCFAs.
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    Journal Title
    European Journal of Nutrition
    DOI
    https://doi.org/10.1007/s00394-017-1456-5
    Note
    This publication has been entered into Griffith Research Online as an Advanced Online Version.
    Subject
    Nutrition and Dietetics not elsewhere classified
    Nutrition and Dietetics
    Publication URI
    http://hdl.handle.net/10072/344522
    Collection
    • Journal articles

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