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dc.contributor.authorIbn Sina, Abu Ali
dc.contributor.authorFoster, Matthew Thomas
dc.contributor.authorKorbie, Darren
dc.contributor.authorCarrascosa, Laura G
dc.contributor.authorShiddiky, Muhammad JA
dc.contributor.authorGao, Jing
dc.contributor.authorDey, Shuvashis
dc.contributor.authorTrau, Matt
dc.date.accessioned2018-07-30T01:30:30Z
dc.date.available2018-07-30T01:30:30Z
dc.date.issued2017
dc.identifier.issn0003-2654
dc.identifier.doi10.1039/C7AN00611J
dc.identifier.urihttp://hdl.handle.net/10072/344962
dc.description.abstractWe report a new multiplexed strategy for the electrochemical detection of regional DNA methylation across multiple regions. Using the sequence dependent affinity of bisulfite treated DNA towards gold surfaces, the method integrates the high sensitivity of micro-fabricated multiplex device comprising microarray of gold electrodes, with the powerful multiplexing capability of multiplex-PCR. The synergy of this combination enables the monitoring of the methylation changes across several genomic regions simultaneously from as low as 500 pg/µl of DNA with no sequencing requirement.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherRoyal Society of Chemistry (RSC) Publications
dc.relation.ispartofpagefrom1
dc.relation.ispartofpageto6
dc.relation.ispartofjournalAnalyst
dc.subject.fieldofresearchAnalytical chemistry
dc.subject.fieldofresearchAnalytical chemistry not elsewhere classified
dc.subject.fieldofresearchOther chemical sciences
dc.subject.fieldofresearchcode3401
dc.subject.fieldofresearchcode340199
dc.subject.fieldofresearchcode3499
dc.titleA multiplex microplatform for the detection of multiple DNA methylation events using gold-DNA affinity
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dc.description.versionAccepted Manuscript (AM)
gro.description.notepublicThis publication has been entered into Griffith Research Online as an Advanced Online Version.
gro.rights.copyright© 2017 Royal Society of Chemistry. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal website for access to the definitive, published version.
gro.hasfulltextFull Text
gro.griffith.authorShiddiky, Muhammad J.


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