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  • Energy demand and supply in human skeletal muscle

    Author(s)
    Barclay, Chris
    Griffith University Author(s)
    Barclay, Chris
    Year published
    2017
    Metadata
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    Abstract
    The energy required for muscle contraction is provided by the breakdown of ATP but the amount of ATP in muscles cells is sufficient to power only a short duration of contraction. Buffering of ATP by phosphocreatine, a reaction catalysed by creatine kinase, extends the duration of activity possible but sustained activity depends on continual regeneration of PCr. This is achieved using ATP generated by oxidative processes and, during intense activity, by anaerobic glycolysis. The rate of ATP breakdown ranges from 70 to 140 mM min−1 during isometric contractions of various intensity to as much as 400 mM min−1 during intense, ...
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    The energy required for muscle contraction is provided by the breakdown of ATP but the amount of ATP in muscles cells is sufficient to power only a short duration of contraction. Buffering of ATP by phosphocreatine, a reaction catalysed by creatine kinase, extends the duration of activity possible but sustained activity depends on continual regeneration of PCr. This is achieved using ATP generated by oxidative processes and, during intense activity, by anaerobic glycolysis. The rate of ATP breakdown ranges from 70 to 140 mM min−1 during isometric contractions of various intensity to as much as 400 mM min−1 during intense, dynamic activity. The maximum rate of oxidative energy supply in untrained people is ~50 mM min−1 which, if the contraction duty cycle is 0.5 as is often the case in cyclic activity, is sufficient to match an ATP breakdown rate during contraction of 100 mM min−1. During brief, intense activity the rate of ATP turnover can exceed the rates of PCr regeneration by combined oxidative and glycolytic energy supply, resulting in a net decrease in PCr concentration. Glycolysis has the capacity to produce between 30 and 50 mM of ATP so that, for example, anaerobic glycolysis could provide ATP at an average of 100 mM min−1 over 30 s of exhausting activity. The creatine kinase reaction plays an important role not only in buffering ATP but also in communicating energy demand from sites of ATP breakdown to the mitochondria. In that role, creatine kinases acts to slow and attenuate the response of mitochondria to changes in energy demand.
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    Journal Title
    Journal of Muscle Research and Cell Motility
    DOI
    https://doi.org/10.1007/s10974-017-9467-7
    Note
    This publication has been entered into Griffith Research Online as an Advanced Online Version.
    Subject
    Physiology not elsewhere classified
    Biochemistry and Cell Biology
    Physiology
    Publication URI
    http://hdl.handle.net/10072/344975
    Collection
    • Journal articles

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