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dc.contributor.authorRogers, KL
dc.contributor.authorGrice, ID
dc.contributor.authorGriffiths, LR
dc.date.accessioned2017-05-03T13:44:19Z
dc.date.available2017-05-03T13:44:19Z
dc.date.issued2000
dc.identifier.issn0928-0987
dc.identifier.doi10.1016/S0928-0987(99)00074-3
dc.identifier.urihttp://hdl.handle.net/10072/3449
dc.description.abstractTo identify potential migraine therapeutics, extracts of eighteen plants were screened to detect plant constituents affecting ADP induced platelet aggregation and [14C]5-hydroxytryptamine (5-HT) release. Extracts of the seven plants exhibiting significant inhibition of platelet function were reanalysed in the presence of polyvinyl pyrrolidone (PVP) to remove polyphenolic tannins that precipitate proteins. Two of these extracts no longer exhibited inhibition of platelet activity after removal of tannins. However, extracts of Crataegus monogyna, Ipomoea pes-caprae, Eremophila freelingii, Eremophila longifolia, and Asteromyrtus symphyocarpa still potently inhibited ADP induced human platelet [14C]5-HT release in vitro, with levels ranging from 62 to 95% inhibition. I. pes-caprae, and C. monogyna also caused significant inhibition of ADP induced platelet aggregation. All of these plants have been previously used as traditional headache treatments, except for C. monogyna which is used primarily for protective effects on the cardiovascular system. Further studies elucidating the compounds that are responsible for these anti-platelet effects are needed to determine their exact mechanism of action.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier Science
dc.publisher.placeNetherlands
dc.relation.ispartofpagefrom355
dc.relation.ispartofpageto363
dc.relation.ispartofjournalEuropean Journal of Pharmaceutical Sciences
dc.relation.ispartofvolume9
dc.subject.fieldofresearchPharmacology and pharmaceutical sciences
dc.subject.fieldofresearchcode3214
dc.titleInhibition of platelet aggregation and 5-HT release by extracts of Australian plants used traditionally as headache treatments
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2015-05-04T22:02:22Z
gro.hasfulltextNo Full Text
gro.griffith.authorGrice, Darren D.


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