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dc.contributor.authorRogers, Kellyen_US
dc.contributor.authorGrice, Darrenen_US
dc.contributor.authorGriffiths, Lynen_US
dc.date.accessioned2017-05-03T13:44:19Z
dc.date.available2017-05-03T13:44:19Z
dc.date.issued2000en_US
dc.identifier.issn09280987en_US
dc.identifier.doi10.1016/S0928-0987(99)00074-3en_US
dc.identifier.urihttp://hdl.handle.net/10072/3449
dc.description.abstractTo identify potential migraine therapeutics, extracts of eighteen plants were screened to detect plant constituents affecting ADP induced platelet aggregation and [14C]5-hydroxytryptamine (5-HT) release. Extracts of the seven plants exhibiting significant inhibition of platelet function were reanalysed in the presence of polyvinyl pyrrolidone (PVP) to remove polyphenolic tannins that precipitate proteins. Two of these extracts no longer exhibited inhibition of platelet activity after removal of tannins. However, extracts of Crataegus monogyna, Ipomoea pes-caprae, Eremophila freelingii, Eremophila longifolia, and Asteromyrtus symphyocarpa still potently inhibited ADP induced human platelet [14C]5-HT release in vitro, with levels ranging from 62 to 95% inhibition. I. pes-caprae, and C. monogyna also caused significant inhibition of ADP induced platelet aggregation. All of these plants have been previously used as traditional headache treatments, except for C. monogyna which is used primarily for protective effects on the cardiovascular system. Further studies elucidating the compounds that are responsible for these anti-platelet effects are needed to determine their exact mechanism of action.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.languageEnglishen_US
dc.language.isoen_US
dc.publisherElsevier Scienceen_US
dc.publisher.placeNetherlandsen_US
dc.relation.ispartofpagefrom355en_US
dc.relation.ispartofpageto363en_US
dc.relation.ispartofjournalEuropean Journal of Pharmaceutical Sciencesen_US
dc.relation.ispartofvolume9en_US
dc.subject.fieldofresearchcode320000en_US
dc.titleInhibition of platelet aggregation and 5-HT release by extracts of Australian plants used traditionally as headache treatmentsen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2015-05-04T22:02:22Z
gro.hasfulltextNo Full Text


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