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dc.contributor.authorWang, Peiyuan
dc.contributor.authorWang, Chengli
dc.contributor.authorLu, Lingfei
dc.contributor.authorLi, Xiaomin
dc.contributor.authorWang, Wenxing
dc.contributor.authorZhao, Mengyao
dc.contributor.authorHu, Lidan
dc.contributor.authorEl-Toni, Ahmed Mohamed
dc.contributor.authorLi, Qin
dc.contributor.authorZhang, Fan
dc.date.accessioned2017-09-15T00:40:19Z
dc.date.available2017-09-15T00:40:19Z
dc.date.issued2017
dc.identifier.issn0142-9612
dc.identifier.doi10.1016/j.biomaterials.2017.06.040
dc.identifier.urihttp://hdl.handle.net/10072/346680
dc.description.abstractEffective delivery of imaging agents or therapeutics to the brain has remained elusive due to the poor blood-brain barrier (BBB) permeability, resulting in the apparent risks of inefficient diagnosis and therapeutic agents for brain disease. Herein, we report on the surface roughness mediated BBB transportation for the first time. The lanthanide-based core/shell/shell structured NaYF4:Yb,Er@NaGdF4:Yb@NaNdF4:Yb nanoplates with controllable surface roughness and multi-model bioimaging features were synthesized and used to evaluate the surface roughness dependent BBB permeability without any surface bio-functionalization. By controlling the kinetics of the shell coating process, the hexagon-disc, multi-petals and six-petals nanoplates with different surface roughness can be obtained. Comparing with the NPs with less Ra and receptor-conjugated NPs, the obtained six-petals nanoplates with highest roughness exhibit excellent performance in BBB transportation and tumor targeting, which lay solid foundation for the diagnosis and the therapy of brain tumor.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofpagefrom223
dc.relation.ispartofpageto232
dc.relation.ispartofjournalBiomaterials
dc.relation.ispartofvolume141
dc.subject.fieldofresearchBiomaterials
dc.subject.fieldofresearchcode400302
dc.titleKinetics-mediate fabrication of multi-model bioimaging lanthanide nanoplates with controllable surface roughness for blood brain barrier transportation
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorLi, Qin


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