Drug discovery processes to drug targeting mechanisms
Embargoed until: 2018-01-01
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Drug discovery in different time frames provides a reflection in the struggle of scientists to generate synthetic products from a natural source. The complex processes exist in the development of the new drug from novel ideas. The duration may vary 10-15 year with estimation cost of $1.5 billion. The stratification of different assays involved in development phase leads to the acceptability of drug molecule. In the discovery phase, implementation of powerful techniques such as combinatorial chemistry and molecular modeling has also participated in the identification of drug target molecules. The advancement in molecular biology especially genomic science has also imparted a profound role in the discovery phase. However, with bioinformatics branch, it allows us to derive more suitable points for attacking the drug molecule in different disease conditions. However, the review will describe the preclinical stages, identification and validation of target through HTS (high throughput screening assay) and finally approval of drug molecule for further clinical development.
International Journal of Pharmacology
Copyright 2017 Asian Network for Scientific Information. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal website for access to the definitive, published version.
Pharmacology and Pharmaceutical Sciences not elsewhere classified