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dc.contributor.authorHadhazi, Adam
dc.contributor.authorPascolutti, Mauro
dc.contributor.authorBailly, Benjamin
dc.contributor.authorDyason, Jeffrey C
dc.contributor.authorBorbas, Aniko
dc.contributor.authorThomson, Robin J
dc.contributor.authorvon Itzstein, Mark
dc.date.accessioned2017-09-15T03:20:43Z
dc.date.available2017-09-15T03:20:43Z
dc.date.issued2017
dc.identifier.issn1477-0520
dc.identifier.doi10.1039/c7ob00947j
dc.identifier.urihttp://hdl.handle.net/10072/346749
dc.description.abstractA new direction for influenza virus sialidase inhibitor development was identified using a sulfonate congener of 2-deoxy-2-β-H N-acetylneuraminic acid. Sialosyl sulfonates can be synthesised efficiently in four steps from N-acetylneuraminic acid via a microwave assisted decarboxylation. The presence of the sulfonate group significantly increases inhibition of influenza virus sialidase and viral infection when compared to the carboxylate congener, and also to the benchmark sialidase inhibitor 2,3-dehydro-2-deoxy-N-acetylneuraminic acid, Neu5Ac2en.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherRSC Publishing
dc.relation.ispartofpagefrom5249
dc.relation.ispartofpageto5253
dc.relation.ispartofissue25
dc.relation.ispartofjournalOrganic and Biomolecular Chemistry
dc.relation.ispartofvolume15
dc.subject.fieldofresearchBioinorganic chemistry
dc.subject.fieldofresearchMedicinal and biomolecular chemistry
dc.subject.fieldofresearchOrganic chemistry
dc.subject.fieldofresearchcode340201
dc.subject.fieldofresearchcode3404
dc.subject.fieldofresearchcode3405
dc.titleA sialosyl sulfonate as a potent inhibitor of influenza virus replication
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyAn Unassigned Group, An Unassigned Department
gro.hasfulltextNo Full Text
gro.griffith.authorvon Itzstein, Mark
gro.griffith.authorThomson, Robin J.
gro.griffith.authorPascolutti, Mauro


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