Show simple item record

dc.contributor.authorRickard, Claire M
dc.contributor.authorMarsh, Nicole M
dc.contributor.authorWebster, Joan
dc.contributor.authorGavin, Nicole C
dc.contributor.authorChan, Raymond J
dc.contributor.authorMcCarthy, Alexandra L
dc.contributor.authorMollee, Peter
dc.contributor.authorUllman, Amanda J
dc.contributor.authorKleidon, Tricia
dc.contributor.authorChopra, Vineet
dc.contributor.authorZhang, Li
dc.contributor.authorMcGrail, Matthew R
dc.contributor.authorLarsen, Emily
dc.contributor.authorAbu Choudhury, Md
dc.contributor.authorKeogh, Samantha
dc.contributor.authorAlexandrou, Evan
dc.contributor.authorMcMillan, David J
dc.contributor.authorMervin, Merehau Cindy
dc.contributor.authorPaterson, David L
dc.contributor.authorCooke, Marie
dc.contributor.authorRay-Barruel, Gillian
dc.contributor.authorCastillo, Maria Isabel
dc.contributor.authorHallahan, Andrew
dc.contributor.authorCorley, Amanda
dc.contributor.authorPlayford, E Geoffrey
dc.date.accessioned2018-06-06T01:00:23Z
dc.date.available2018-06-06T01:00:23Z
dc.date.issued2017
dc.identifier.issn2044-6055
dc.identifier.doi10.1136/bmjopen-2016-015291
dc.identifier.urihttp://hdl.handle.net/10072/347126
dc.description.abstractIntroduction: Around 30% of peripherally inserted central catheters (PICCs) fail from vascular, infectious or mechanical complications. Patients with cancer are at highest risk, and this increases morbidity, mortality and costs. Effective PICC dressing and securement may prevent PICC failure; however, no large randomised controlled trial (RCT) has compared alternative approaches. We designed this RCT to assess the clinical and cost-effectiveness of dressing and securements to prevent PICC failure. Methods and analysis: Pragmatic, multicentre, 2×2 factorial, superiority RCT of (1) dressings (chlorhexidine gluconate disc (CHG) vs no disc) and (2) securements (integrated securement dressing (ISD) vs securement device (SED)). A qualitative evaluation using a knowledge translation framework is included. Recruitment of 1240 patients will occur over 3 years with allocation concealment until randomisation by a centralised service. For the dressing hypothesis, we hypothesise CHG discs will reduce catheter-associated bloodstream infection (CABSI) compared with no CHG disc. For the securement hypothesis, we hypothesise that ISD will reduce composite PICC failure (infection (CABSI/local infection), occlusion, dislodgement or thrombosis), compared with SED. Secondary outcomes: types of PICC failure; safety; costs; dressing/securement failure; dwell time; microbial colonisation; reversible PICC complications and consumer acceptability. Relative incidence rates of CABSI and PICC failure/100 devices and/1000 PICC days (with 95% CIs) will summarise treatment impact. Kaplan-Meier survival curves (and log rank Mantel-Haenszel test) will compare outcomes over time. Secondary end points will be compared between groups using parametric/non-parametric techniques; p values <0.05 will be considered to be statistically significant.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherBMJ Publishing Group
dc.relation.ispartofpagefrome015291-1
dc.relation.ispartofpagetoe015291-8
dc.relation.ispartofissue6
dc.relation.ispartofjournalBMJ Open
dc.relation.ispartofvolume7
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchHealth services and systems
dc.subject.fieldofresearchPublic health
dc.subject.fieldofresearchOther health sciences
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchHealth sciences
dc.subject.fieldofresearchPsychology
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode4203
dc.subject.fieldofresearchcode4206
dc.subject.fieldofresearchcode4299
dc.subject.fieldofresearchcode32
dc.subject.fieldofresearchcode42
dc.subject.fieldofresearchcode52
dc.titlePeripherally InSerted CEntral catheter dressing and securement in patients with cancer: the PISCES trial. Protocol for a 2x2 factorial, superiority randomised controlled trial
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by-nc/4.0/
dc.description.versionVersion of Record (VoR)
gro.facultyGriffith Health, School of Nursing and Midwifery
gro.rights.copyright© The Authors, 2017. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
gro.hasfulltextFull Text
gro.griffith.authorCooke, Marie L.
gro.griffith.authorMcCarthy, Sandie L.
gro.griffith.authorCorley, Amanda
gro.griffith.authorLarsen, Emily N.


Files in this item

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record