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  • Focusing in on structural genomics: The University of Queensland structural biology pipeline

    Author(s)
    Puri, Munish
    Robin, Gautier
    Cowieson, Nathan
    Forwood, Jade K
    Listwan, Pawel
    hu, S-Hong Hu
    Guncar, Gregor
    Huber, Thomas
    Kellie, Stuart
    Hume, David A
    Kobe, Bostjan
    Martin, Jennifer L
    Griffith University Author(s)
    Martin, Jennifer
    Year published
    2006
    Metadata
    Show full item record
    Abstract
    The flood of new genomic sequence information together with technological innovations in protein structure determination have led to worldwide structural genomics (SG) initiatives. The goals of SG initiatives are to accelerate the process of protein structure determination, to fill in protein fold space and to provide information about the function of uncharacterized proteins. In the long-term, these outcomes are likely to impact on medical biotechnology and drug discovery, leading to a better understanding of disease as well as the development of new therapeutics. Here we describe the high throughput pipeline established ...
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    The flood of new genomic sequence information together with technological innovations in protein structure determination have led to worldwide structural genomics (SG) initiatives. The goals of SG initiatives are to accelerate the process of protein structure determination, to fill in protein fold space and to provide information about the function of uncharacterized proteins. In the long-term, these outcomes are likely to impact on medical biotechnology and drug discovery, leading to a better understanding of disease as well as the development of new therapeutics. Here we describe the high throughput pipeline established at the University of Queensland in Australia. In this focused pipeline, the targets for structure determination are proteins that are expressed in mouse macrophage cells and that are inferred to have a role in innate immunity. The aim is to characterize the molecular structure and the biochemical and cellular function of these targets by using a parallel processing pipeline. The pipeline is designed to work with tens to hundreds of target gene products and comprises target selection, cloning, expression, purification, crystallization and structure determination. The structures from this pipeline will provide insights into the function of previously uncharacterized macrophage proteins and could lead to the validation of new drug targets for chronic obstructive pulmonary disease and arthritis.
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    Journal Title
    Biomolecular Engineering
    Volume
    23
    Issue
    6
    DOI
    https://doi.org/10.1016/j.bioeng.2006.09.002
    Subject
    Biological sciences
    Biochemistry and cell biology not elsewhere classified
    Publication URI
    http://hdl.handle.net/10072/347425
    Collection
    • Journal articles

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