dc.contributor.author | Boyd, Roslyn N | |
dc.contributor.author | Jordan, Rachel | |
dc.contributor.author | Pareezer, Laura | |
dc.contributor.author | Moodie, Anne | |
dc.contributor.author | Finn, Christine | |
dc.contributor.author | Luther, Belinda | |
dc.contributor.author | Arnfield, Evyn | |
dc.contributor.author | Pym, Aaron | |
dc.contributor.author | Craven, Alex | |
dc.contributor.author | Beall, Paula | |
dc.contributor.author | Weir, Kelly | |
dc.contributor.author | Kentish, Megan | |
dc.contributor.author | Wynter, Meredith | |
dc.contributor.author | Ware, Robert | |
dc.contributor.author | Fahey, Michael | |
dc.contributor.author | Rawicki, Barry | |
dc.contributor.author | McKinlay, Lynne | |
dc.contributor.author | Guzzetta, Andrea | |
dc.date.accessioned | 2017-10-12T01:34:51Z | |
dc.date.available | 2017-10-12T01:34:51Z | |
dc.date.issued | 2013 | |
dc.identifier.issn | 1471-2377 | |
dc.identifier.doi | 10.1186/1471-2377-13-57 | |
dc.identifier.uri | http://hdl.handle.net/10072/348527 | |
dc.description.abstract | Background: Cerebral palsy (CP) results from a static brain lesion during pregnancy or early life and remains the
most common cause of physical disability in children (1 in 500). While the brain lesion is static, the physical
manifestations and medical issues may progress resulting in altered motor patterns. To date, there are no
prospective longitudinal studies of CP that follow a birth cohort to track early gross and fine motor development
and use Magnetic Resonance Imaging (MRI) to determine the anatomical pattern and likely timing of the brain
lesion. Existing studies do not consider treatment costs and outcomes. This study aims to determine the pathway(s)
to motor outcome from diagnosis at 18 months corrected age (c.a.) to outcome at 5 years in relation to the nature
of the brain lesion (using structural MRI).
Methods: This prospective cohort study aims to recruit a total of 240 children diagnosed with CP born in Victoria
(birth years 2004 and 2005) and Queensland (birth years 2006–2009). Children can enter the study at any time
between 18 months to 5 years of age and will be assessed at 18, 24, 30, 36, 48 and 60 months c.a. Outcomes
include gross motor function (GMFM-66 & GMFM-88), Gross Motor Function Classification System (GMFCS);
musculoskeletal development (hip displacement, spasticity, muscle contracture), upper limb function (Manual Ability
Classification System), communication difficulties using Communication and Symbolic Behaviour ScalesDevelopmental
Profile (CSBS-DP), participation using the Paediatric Evaluation of Disability Inventory (PEDI), parent
reported quality of life and classification of medical and allied health resource use and determination of the
aetiology of CP using clinical evaluation combined with MRI. The relationship between the pathways to motor
outcome and the nature of the brain lesion will be analysed using multiple methods including non-linear
modelling, multilevel mixed-effects models and generalised estimating equations.
Discussion: This protocol describes a large population-based study of early motor development and brain structure
in a representative sample of preschool aged children with CP, using direct clinical assessment. The results of this
study will be published in peer reviewed journals and presented at relevant international conferences. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | BioMed Central Ltd. | |
dc.relation.ispartofpagefrom | 57-1 | |
dc.relation.ispartofpageto | 57-12 | |
dc.relation.ispartofjournal | BMC Neurology | |
dc.relation.ispartofvolume | 13 | |
dc.subject.fieldofresearch | Allied health and rehabilitation science | |
dc.subject.fieldofresearch | Neurology and neuromuscular diseases | |
dc.subject.fieldofresearch | Nutrition and dietetics | |
dc.subject.fieldofresearch | Paediatrics | |
dc.subject.fieldofresearchcode | 4201 | |
dc.subject.fieldofresearchcode | 320905 | |
dc.subject.fieldofresearchcode | 3210 | |
dc.subject.fieldofresearchcode | 3213 | |
dc.title | Australian Cerebral Palsy Child Study: Protocol of a prospective population based study of motor and brain development of preschool aged children with cerebral palsy | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
dcterms.license | http://creativecommons.org/licenses/by/2.0 | |
dc.description.version | Version of Record (VoR) | |
gro.description.notepublic | Page numbers are not for citation purposes. Instead, this article has the unique article number of 57. | |
gro.rights.copyright | © 2013 Boyd et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative\rCommons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and\rreproduction in any medium, provided the original work is properly cited. | |
gro.hasfulltext | Full Text | |
gro.griffith.author | Ware, Robert | |