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dc.contributor.authorBoyd, Roslyn N
dc.contributor.authorJordan, Rachel
dc.contributor.authorPareezer, Laura
dc.contributor.authorMoodie, Anne
dc.contributor.authorFinn, Christine
dc.contributor.authorLuther, Belinda
dc.contributor.authorArnfield, Evyn
dc.contributor.authorPym, Aaron
dc.contributor.authorCraven, Alex
dc.contributor.authorBeall, Paula
dc.contributor.authorWeir, Kelly
dc.contributor.authorKentish, Megan
dc.contributor.authorWynter, Meredith
dc.contributor.authorWare, Robert
dc.contributor.authorFahey, Michael
dc.contributor.authorRawicki, Barry
dc.contributor.authorMcKinlay, Lynne
dc.contributor.authorGuzzetta, Andrea
dc.date.accessioned2017-10-12T01:34:51Z
dc.date.available2017-10-12T01:34:51Z
dc.date.issued2013
dc.identifier.issn1471-2377
dc.identifier.doi10.1186/1471-2377-13-57
dc.identifier.urihttp://hdl.handle.net/10072/348527
dc.description.abstractBackground: Cerebral palsy (CP) results from a static brain lesion during pregnancy or early life and remains the most common cause of physical disability in children (1 in 500). While the brain lesion is static, the physical manifestations and medical issues may progress resulting in altered motor patterns. To date, there are no prospective longitudinal studies of CP that follow a birth cohort to track early gross and fine motor development and use Magnetic Resonance Imaging (MRI) to determine the anatomical pattern and likely timing of the brain lesion. Existing studies do not consider treatment costs and outcomes. This study aims to determine the pathway(s) to motor outcome from diagnosis at 18 months corrected age (c.a.) to outcome at 5 years in relation to the nature of the brain lesion (using structural MRI). Methods: This prospective cohort study aims to recruit a total of 240 children diagnosed with CP born in Victoria (birth years 2004 and 2005) and Queensland (birth years 2006–2009). Children can enter the study at any time between 18 months to 5 years of age and will be assessed at 18, 24, 30, 36, 48 and 60 months c.a. Outcomes include gross motor function (GMFM-66 & GMFM-88), Gross Motor Function Classification System (GMFCS); musculoskeletal development (hip displacement, spasticity, muscle contracture), upper limb function (Manual Ability Classification System), communication difficulties using Communication and Symbolic Behaviour ScalesDevelopmental Profile (CSBS-DP), participation using the Paediatric Evaluation of Disability Inventory (PEDI), parent reported quality of life and classification of medical and allied health resource use and determination of the aetiology of CP using clinical evaluation combined with MRI. The relationship between the pathways to motor outcome and the nature of the brain lesion will be analysed using multiple methods including non-linear modelling, multilevel mixed-effects models and generalised estimating equations. Discussion: This protocol describes a large population-based study of early motor development and brain structure in a representative sample of preschool aged children with CP, using direct clinical assessment. The results of this study will be published in peer reviewed journals and presented at relevant international conferences.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherBioMed Central Ltd.
dc.relation.ispartofpagefrom57-1
dc.relation.ispartofpageto57-12
dc.relation.ispartofjournalBMC Neurology
dc.relation.ispartofvolume13
dc.subject.fieldofresearchAllied health and rehabilitation science
dc.subject.fieldofresearchNeurology and neuromuscular diseases
dc.subject.fieldofresearchNutrition and dietetics
dc.subject.fieldofresearchPaediatrics
dc.subject.fieldofresearchcode4201
dc.subject.fieldofresearchcode320905
dc.subject.fieldofresearchcode3210
dc.subject.fieldofresearchcode3213
dc.titleAustralian Cerebral Palsy Child Study: Protocol of a prospective population based study of motor and brain development of preschool aged children with cerebral palsy
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by/2.0
dc.description.versionVersion of Record (VoR)
gro.description.notepublicPage numbers are not for citation purposes. Instead, this article has the unique article number of 57.
gro.rights.copyright© 2013 Boyd et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative\rCommons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and\rreproduction in any medium, provided the original work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorWare, Robert


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