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dc.contributor.authorCaesar, Rebecca
dc.contributor.authorBoyd, Roslyn N
dc.contributor.authorColditz, Paul
dc.contributor.authorCioni, Giovani
dc.contributor.authorWare, Robert S
dc.contributor.authorSalthouse, Kaye
dc.contributor.authorDoherty, Julie
dc.contributor.authorJackson, Maxine
dc.contributor.authorMatthews, Leanne
dc.contributor.authorHurley, Tom
dc.contributor.authorMorosini, Anthony
dc.contributor.authorThomas, Clare
dc.contributor.authorCamadoo, Laxmi
dc.contributor.authorBaer, Erica
dc.date.accessioned2017-10-12T03:03:46Z
dc.date.available2017-10-12T03:03:46Z
dc.date.issued2016
dc.identifier.issn2044-6055
dc.identifier.doi10.1136/bmjopen-2015-010726
dc.identifier.urihttp://hdl.handle.net/10072/348537
dc.description.abstractIntroduction: Over 80% of very preterm (<32 weeks) and very low birthweight (<1500 g) infants will have either typical development (TD) or mild developmental delay (MDD) in multiple domains. As differentiation between TD and MDD can be difficult, infants with MDD often miss opportunities for intervention. For many clinicians, the ongoing challenge is early detection of MDD without over servicing the population. This study aims to: (1) identify early clinical biomarkers for use in this population to predict and differentiate between TD and MDD at 24 months corrected age. (2) Determine the extent to which family and caregiver factors will contribute to neurodevelopmental and behavioural outcomes. Methods and analysis: Participants will be a prospective cohort of 90 infants (<32 weeks and/or <1500 g). Between 34 weeks gestational age and 16 weeks post-term, infants will have a series of 5 neurological, neuromotor, neurobehavioural and perceptual assessments including General Movement Assessment at preterm, writhing and fidgety age. Primary caregivers will complete questionnaires to identify social risk, maternal depression and family strain. Extensive perinatal data will be collected from the medical record. At 24 months, corrected age (c.a) infants will be assessed using standardised tools including the Bayley Scales of Infant and Toddler Development—Third Edition (Bayley III). Longitudinal trajectories of early assessment findings will be examined to determine any predictive relationship with motor and cognitive outcomes at 24 months c.a. Published data of a cohort of Australian children assessed with the Bayley III at 24 months c.a will provide a reference group of term-born controls. Ethics: Ethical approval has been obtained from the Queensland Children’s Health Services Human Research Ethics Committee (HREC/13/QRCH/66), the University of Queensland (2013001019) and the Sunshine Coast Hospital and Health Service, SC-Research Governance (SSA/13/QNB/66). Publication of all study outcomes will be in peerreviewed journals.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherBMJ Publishing Group
dc.relation.ispartofpagefrome010726-1
dc.relation.ispartofpagetoe010726-16
dc.relation.ispartofissue7
dc.relation.ispartofjournalBMJ Open
dc.relation.ispartofvolume6
dc.subject.fieldofresearchPaediatrics and Reproductive Medicine not elsewhere classified
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchPublic Health and Health Services
dc.subject.fieldofresearchOther Medical and Health Sciences
dc.subject.fieldofresearchcode111499
dc.subject.fieldofresearchcode1103
dc.subject.fieldofresearchcode1117
dc.subject.fieldofresearchcode1199
dc.titleEarly prediction of typical outcome and mild developmental delay for prioritisation of service delivery for very preterm and very low birthweight infants: A study protocol
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© The Author(s) 2016. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
gro.hasfulltextFull Text
gro.griffith.authorWare, Robert
gro.griffith.authorMorosini, Anthony


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