dc.contributor.author | Caesar, Rebecca | |
dc.contributor.author | Boyd, Roslyn N | |
dc.contributor.author | Colditz, Paul | |
dc.contributor.author | Cioni, Giovani | |
dc.contributor.author | Ware, Robert S | |
dc.contributor.author | Salthouse, Kaye | |
dc.contributor.author | Doherty, Julie | |
dc.contributor.author | Jackson, Maxine | |
dc.contributor.author | Matthews, Leanne | |
dc.contributor.author | Hurley, Tom | |
dc.contributor.author | Morosini, Anthony | |
dc.contributor.author | Thomas, Clare | |
dc.contributor.author | Camadoo, Laxmi | |
dc.contributor.author | Baer, Erica | |
dc.date.accessioned | 2017-10-12T03:03:46Z | |
dc.date.available | 2017-10-12T03:03:46Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 2044-6055 | |
dc.identifier.doi | 10.1136/bmjopen-2015-010726 | |
dc.identifier.uri | http://hdl.handle.net/10072/348537 | |
dc.description.abstract | Introduction: Over 80% of very preterm (<32 weeks)
and very low birthweight (<1500 g) infants will have
either typical development (TD) or mild developmental
delay (MDD) in multiple domains. As differentiation
between TD and MDD can be difficult, infants with
MDD often miss opportunities for intervention. For
many clinicians, the ongoing challenge is early
detection of MDD without over servicing the
population. This study aims to: (1) identify early
clinical biomarkers for use in this population
to predict and differentiate between TD and
MDD at 24 months corrected age. (2) Determine the
extent to which family and caregiver factors will
contribute to neurodevelopmental and behavioural
outcomes.
Methods and analysis: Participants will be a
prospective cohort of 90 infants (<32 weeks and/or
<1500 g). Between 34 weeks gestational age and
16 weeks post-term, infants will have a series of
5 neurological, neuromotor, neurobehavioural and
perceptual assessments including General Movement
Assessment at preterm, writhing and fidgety age.
Primary caregivers will complete questionnaires to
identify social risk, maternal depression and family
strain. Extensive perinatal data will be collected from
the medical record. At 24 months, corrected age (c.a)
infants will be assessed using standardised tools
including the Bayley Scales of Infant and Toddler
Development—Third Edition (Bayley III). Longitudinal
trajectories of early assessment findings
will be examined to determine any predictive
relationship with motor and cognitive outcomes at
24 months c.a. Published data of a cohort of
Australian children assessed with the Bayley III at
24 months c.a will provide a reference group
of term-born controls.
Ethics: Ethical approval has been obtained from the
Queensland Children’s Health Services Human
Research Ethics Committee (HREC/13/QRCH/66), the
University of Queensland (2013001019) and the
Sunshine Coast Hospital and Health Service,
SC-Research Governance (SSA/13/QNB/66).
Publication of all study outcomes will be in peerreviewed
journals. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | BMJ Publishing Group | |
dc.relation.ispartofpagefrom | e010726-1 | |
dc.relation.ispartofpageto | e010726-16 | |
dc.relation.ispartofissue | 7 | |
dc.relation.ispartofjournal | BMJ Open | |
dc.relation.ispartofvolume | 6 | |
dc.subject.fieldofresearch | Clinical sciences | |
dc.subject.fieldofresearch | Reproductive medicine not elsewhere classified | |
dc.subject.fieldofresearch | Health services and systems | |
dc.subject.fieldofresearch | Public health | |
dc.subject.fieldofresearch | Other health sciences | |
dc.subject.fieldofresearchcode | 3202 | |
dc.subject.fieldofresearchcode | 321599 | |
dc.subject.fieldofresearchcode | 4203 | |
dc.subject.fieldofresearchcode | 4206 | |
dc.subject.fieldofresearchcode | 4299 | |
dc.title | Early prediction of typical outcome and mild developmental delay for prioritisation of service delivery for very preterm and very low birthweight infants: A study protocol | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
dcterms.license | http://creativecommons.org/licenses/by/4.0/ | |
dc.description.version | Version of Record (VoR) | |
gro.rights.copyright | © The Author(s) 2016. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ | |
gro.hasfulltext | Full Text | |
gro.griffith.author | Ware, Robert | |