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dc.contributor.authorPetlin, DG
dc.contributor.authorAmarah, AA
dc.contributor.authorTverdokhlebov, SI
dc.contributor.authorAnissimov, YG
dc.date.accessioned2017-10-12T23:56:41Z
dc.date.available2017-10-12T23:56:41Z
dc.date.issued2017
dc.identifier.issn0168-3659
dc.identifier.doi10.1016/j.jconrel.2017.05.021
dc.identifier.urihttp://hdl.handle.net/10072/348628
dc.description.abstractSustained drug release can be achieved by loading a drug into polymer material. The drug release can then be controlled for potential use in various biomedical applications. A model for drug release from a polymeric fibrous scaffold, which takes into account the distribution of fiber diameters within its structure, is developed here. It is demonstrated that the fiber diameter distribution significantly affects the drug release profile from electrospun scaffolds. The developed model indicates that altering the fiber distribution can be used as an additional tool to achieve an appropriate drug release profile. Using published data, it was demonstrated that an application of the model allows a more precise calculation of the drug diffusion coefficient within the polymer, which is important for predicting drug release rates from fabricated materials.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofpagefrom218
dc.relation.ispartofpageto225
dc.relation.ispartofjournalJournal of Controlled Release
dc.relation.ispartofvolume258
dc.subject.fieldofresearchBiomedical engineering
dc.subject.fieldofresearchChemical engineering
dc.subject.fieldofresearchPharmacology and pharmaceutical sciences
dc.subject.fieldofresearchPharmacology and pharmaceutical sciences not elsewhere classified
dc.subject.fieldofresearchcode4003
dc.subject.fieldofresearchcode4004
dc.subject.fieldofresearchcode3214
dc.subject.fieldofresearchcode321499
dc.titleA fiber distribution model for predicting drug release rates
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Sciences, School of Natural Sciences
gro.hasfulltextNo Full Text
gro.griffith.authorAnissimov, Yuri G.
gro.griffith.authorAmarah, Ali Ahmed Amarah
gro.griffith.authorPetlin, Dan


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