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dc.contributor.authorMoyle, Wendy
dc.contributor.authorEl Saifi, Najwan
dc.contributor.authorDraper, Brian
dc.contributor.authorJones, Cindy
dc.contributor.authorBeattie, Elizabeth
dc.contributor.authorShum, David
dc.contributor.authorThalib, Lukman
dc.contributor.authorMervin, Cindy
dc.contributor.authorO'Dwyer, Siobhan
dc.date.accessioned2017-10-13T04:49:47Z
dc.date.available2017-10-13T04:49:47Z
dc.date.issued2017
dc.identifier.issn1574-8863
dc.identifier.doi10.2174/1574886312666170209113203
dc.identifier.urihttp://hdl.handle.net/10072/348638
dc.description.abstractBackground: Neuropsychiatric symptoms of dementia are often treated through the prescription of one or more psychotropic medications. However, limited efficacy and potential harmful side-effects has resulted in efforts to reduce the use of psychotropic medication in this population, particularly for those living in long-term care. Objectives: This study sought to describe the pattern of central nervous system medication usage in older adults with dementia living in long-term care; assess the appropriateness of prescribing against Beers criteria; and detect potential drug interactions from co-administered medications. Methods: A retrospective descriptive audit of the medical records of n=415 residents, aged >60 years with a diagnosis of dementia, from 28 long-term care facilities in Queensland, Australia. Information extracted included the types and usage of regular and Pro Re Nata central nervous system medications. Results: Of those taking medication (n=317), 68% were prescribed at least one potentially inappropriate medication, and there was a significant positive correlation between the number of medications prescribed and the number of potentially inappropriate medications. Two-hundred potential interactions with variable severity were identified from 130 residents on ≥ 1 medication – 38% were potentially severe interactions, 46% were moderate. Conclusion: This medication audit raises concerns that prescription of medications may still be the first resort to treat behavioural and psychological symptoms of dementia. There is a need for effective and sustainable person-centred interventions that address barriers for appropriate prescribing practice, and involve the collaboration of all healthcare professionals to optimise prescribing and improve the quality of medicines in older people with dementia.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherBentham Science Publishers
dc.relation.ispartofpagefrom95
dc.relation.ispartofpageto102
dc.relation.ispartofissue2
dc.relation.ispartofjournalCurrent Drug Safety
dc.relation.ispartofvolume12
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchTraditional, complementary and integrative medicine
dc.subject.fieldofresearchPharmacology and pharmaceutical sciences
dc.subject.fieldofresearchPharmacology and pharmaceutical sciences not elsewhere classified
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode4208
dc.subject.fieldofresearchcode3214
dc.subject.fieldofresearchcode321499
dc.titlePharmacotherapy of Persons with Dementia in Long-term Care in Australia: A Descriptive Audit of Central Nervous System Medications
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dc.description.versionVersion of Record (VoR)
gro.facultyGriffith Health, School of Nursing and Midwifery
gro.rights.copyright© 2017 Bentham Science Publishers. This is an open-access article distributed under the terms of Bentham Science Open Access Plus license (http://benthamscience.com/open-access-plus-main.php) which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The published manuscript is available at EurekaSelect via 10.2174/1574886312666170209113203.
gro.hasfulltextFull Text
gro.griffith.authorMoyle, Wendy


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