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dc.contributor.authorDavenport, Victoriaen_US
dc.contributor.authorGroves, Eleanoren_US
dc.contributor.authorE. Horton, Rachelen_US
dc.contributor.authorG. Hobbs, Christopheren_US
dc.contributor.authorGuthrie, Terryen_US
dc.contributor.authorFindlow, Jamieen_US
dc.contributor.authorBorrow, Rayen_US
dc.contributor.authorM. Næss, Lisbethen_US
dc.contributor.authorOster, Philippen_US
dc.contributor.authorS. Heyderman, Roberten_US
dc.contributor.authorA. Williams, Neilen_US
dc.date.accessioned2017-05-03T15:35:06Z
dc.date.available2017-05-03T15:35:06Z
dc.date.issued2008en_US
dc.date.modified2010-11-05T08:06:44Z
dc.identifier.issn00221899en_US
dc.identifier.doi10.1086/590669en_AU
dc.identifier.urihttp://hdl.handle.net/10072/34913
dc.description.abstractBACKGROUND: Nasopharyngeal carriage of meningococcus or related species leads to protective immunity in adolescence or early adulthood. This natural immunity is associated with mucosal and systemic T cell memory. Whether parenteral Neisseria meningitidis serogroup B (MenB) vaccination influences natural mucosal immunity is unknown. OBJECTIVES: To determine whether parenteral MenB vaccination affects mucosal immunity in young adults and whether this immunity differs from that induced in the blood. METHODS: Otherwise healthy volunteers were immunized with MenB outer membrane vesicle vaccine before and after routine tonsillectomy. Mucosal and systemic immunity were assessed in 9 vaccinees and 12 unvaccinated control subjects by measuring mononuclear cell proliferation, cytokine production, Th1/Th2 surface marker expression, and antibody to MenB antigens. RESULTS: Parenteral vaccination induced a marked increase in systemic T cell immunity against MenB and a Th1 bias. In contrast, although mucosal T cell proliferation in response to MenB neither increased nor decreased following vaccination, mononuclear cell interferon gamma, interleukin (IL)-5, and IL-10 production increased, and the Th1/Th2 profile lost its Th1 bias. CONCLUSIONS: Parenteral MenB vaccination selectively reprograms preexisting naturally acquired mucosal immunity. As new-generation protein-based MenB vaccine candidates undergo evaluation, the impact of these vaccines on mucosal immunity in both adults and children will need to be addressed.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.format.extent551843 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherUniversity of Chicago Pressen_US
dc.publisher.placeUnited Statesen_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom731en_US
dc.relation.ispartofpageto740en_US
dc.relation.ispartofissue5en_US
dc.relation.ispartofjournalJournal of Infectious Diseasesen_US
dc.relation.ispartofvolume198en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchImmunology not elsewhere classifieden_US
dc.subject.fieldofresearchcode110799en_US
dc.titleMucosal immunity in healthy adults after parenteral vaccination with outer-membrane vesicles from Neisseria meningitidis serogroup Ben_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.rights.copyrightCopyright 2008 by University of Chicago Press. The attached file is reproduced here in accordance with the copyright policy of the publisher. First published in Journal of Infectious Diseases, 2008;198:731–740. Please refer to the journal's website for access to the definitive, published version.en_AU
gro.date.issued2008
gro.hasfulltextFull Text


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