dc.contributor.author | McManus, K | |
dc.contributor.author | Wood, A | |
dc.contributor.author | Wright, MH | |
dc.contributor.author | Matthews, B | |
dc.contributor.author | Greene, AC | |
dc.contributor.author | Cock, IE | |
dc.date.accessioned | 2017-10-27T06:24:49Z | |
dc.date.available | 2017-10-27T06:24:49Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 0142-5463 | |
dc.identifier.doi | 10.1111/ics.12403 | |
dc.identifier.uri | http://hdl.handle.net/10072/350069 | |
dc.description.abstract | OBJECTIVE: Terminalia ferdinandiana extracts are potent growth
inhibitors of many bacterial pathogens. They may also inhibit the
growth of malodour-producing bacteria and thus be useful deodorant
components, although this is yet to be tested.
METHODS: Terminalia ferdinandiana fruit and leaf solvent extracts
were investigated by disc diffusion and liquid dilution MIC assays
against the most significant bacterial contributors to axillary and
plantar malodour formation. Toxicity was determined using the
Artemia franciscana nauplii bioassay. Non-targeted HPLC separation
of the methanolic leaf extract coupled to high-resolution time-of-
flight (TOF) mass spectroscopy was used for the identification and
characterization of individual components in the extract.
RESULTS: The T. ferdinandiana leaf extracts were the most potent
bacterial growth inhibitors. The leaf methanolic extract was
particularly potent, with low MIC values against C. jeikeium
(233 lg mL 1
), S. epidermidis (220 lg mL 1
), P. acnes (625 lg
mL 1
) and B. linens (523 lg mL 1
). The aqueous and ethyl acetate
leaf extracts were also potent growth inhibitors of C. jeikeium and
S. epidermidis (MICs < 1000 lg mL 1
). In comparison, the fruit
extracts were substantially less potent antibacterial agents,
although still with MIC values indicative of moderate growth inhibitory
activity. All T. ferdinandiana leaf extracts were non-toxic in
the Artemia franciscana bioassay. Non-biased phytochemical analysis
of the methanolic leaf extract revealed the presence of high levels
of and high diversity of tannins and high levels of the flavone luteolin.
CONCLUSION: The low toxicity of the T. ferdinandiana leaf extracts
and their potent growth inhibition of axillary and plantar
malodour-producing bacteria indicate their potential as deodorant | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Wiley-Blackwell Publishing | |
dc.relation.ispartofpagefrom | 500 | |
dc.relation.ispartofpageto | 510 | |
dc.relation.ispartofissue | 5 | |
dc.relation.ispartofjournal | International Journal of Cosmetic Science | |
dc.relation.ispartofvolume | 39 | |
dc.subject.fieldofresearch | Medicinal and biomolecular chemistry | |
dc.subject.fieldofresearch | Natural products and bioactive compounds | |
dc.subject.fieldofresearch | Clinical sciences | |
dc.subject.fieldofresearch | Allied health and rehabilitation science | |
dc.subject.fieldofresearchcode | 3404 | |
dc.subject.fieldofresearchcode | 340502 | |
dc.subject.fieldofresearchcode | 3202 | |
dc.subject.fieldofresearchcode | 4201 | |
dc.title | Terminalia ferdinandiana Exell. Extracts inhibit the growth of body odour-forming bacteria | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.faculty | Arts, Education & Law Group, School of Education and Professional Studies | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Cock, Ian E. | |
gro.griffith.author | Greene, Tony C. | |