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dc.contributor.authorCarless, MA
dc.contributor.authorCurran, JE
dc.contributor.authorGaffney, P
dc.contributor.authorWeinstein, SR
dc.contributor.authorGriffiths, LR
dc.contributor.editornot stated
dc.date.accessioned2017-05-03T13:33:49Z
dc.date.available2017-05-03T13:33:49Z
dc.date.issued2001
dc.identifier.issn0304-3835
dc.identifier.doi10.1016/S0304-3835(01)00442-6
dc.identifier.urihttp://hdl.handle.net/10072/3500
dc.description.abstractThe presence of somatostatin receptors (SSTR1-5) in tumour cells indicates a potential for somatostatin to bind and suppress growth, as well as allowing for therapeutic treatment with somatostatin analogues. The genes for SSTR1 and SSTR2 have been shown to contain dinucleotide repeat polymorphisms. We have performed association studies on breast cancer and solar keratosis populations to determine whether these genes play a role in the development of these conditions. Results showed that there was no significant difference between SSTR1 and SSTR2 polymorphism frequencies in the tested breast cancer population (P=0.59 and P=0.54, respectively) nor the solar keratosis population (P=0.10 and P=0.883, respectively) as compared to unaffected populations. Hence, these studies do not support a role for these receptor genes in either breast cancer or solar keratosis lesions.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier Science
dc.publisher.placeIreland
dc.relation.ispartofpagefrom193
dc.relation.ispartofpageto197
dc.relation.ispartofjournalCancer Letters
dc.relation.ispartofvolume166
dc.subject.fieldofresearchOncology and carcinogenesis
dc.subject.fieldofresearchcode3211
dc.titleAssociation analysis of somatostatin receptor (SSTR1 and SSTR2) polymorphisms in breast cancer and solar keratosis.
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Medical Science
gro.date.issued2015-05-04T22:05:05Z
gro.hasfulltextNo Full Text
gro.griffith.authorGaffney, Philip T.
gro.griffith.authorGriffiths, Lyn
gro.griffith.authorCurran, Joanne E.
gro.griffith.authorCarless, Melanie
gro.griffith.authorWeinstein, Stephen R.


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