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  • Pestalactams A-C: Novel Caprolactams from the Endophytic Fungus Pestalotiopsis sp.

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    Author(s)
    Davis, Rohan A
    Carroll, Anthony R
    Andrews, Katherine T
    Boyle, Glen M
    Tran, Truc Linh
    Healy, Peter C
    Kalaitzis, John A
    Shivas, Roger G
    Griffith University Author(s)
    Healy, Peter C.
    Andrews, Katherine T.
    Davis, Rohan A.
    Carroll, Anthony R.
    Year published
    2010
    Metadata
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    Abstract
    Chemical investigations of a fermentation culture from the endophytic fungus Pestalotiopsis sp. yielded three novel caprolactams, pestalactams A-C (1-3). The structures of 1-3 were determined by analysis of 1D and 2D-NMR, UV, IR, and MS data. The structure of pestalactam A was confirmed following single crystal X-ray diffraction analysis. Pestalactams A-C are the first C-7 alkylated caprolactam natural products to be reported. Pestalactams A (1) and B (2) were tested against two different strains of the malaria parasite Plasmodium falciparum (3D7 and Dd2), and the mammalian cell lines, MCF-7 and NFF, and showed modest ...
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    Chemical investigations of a fermentation culture from the endophytic fungus Pestalotiopsis sp. yielded three novel caprolactams, pestalactams A-C (1-3). The structures of 1-3 were determined by analysis of 1D and 2D-NMR, UV, IR, and MS data. The structure of pestalactam A was confirmed following single crystal X-ray diffraction analysis. Pestalactams A-C are the first C-7 alkylated caprolactam natural products to be reported. Pestalactams A (1) and B (2) were tested against two different strains of the malaria parasite Plasmodium falciparum (3D7 and Dd2), and the mammalian cell lines, MCF-7 and NFF, and showed modest in vitro activity in all assays.
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    Journal Title
    Organic & Biomolecular Chemistry
    Volume
    8
    Issue
    8
    DOI
    https://doi.org/10.1039/B924169H
    Copyright Statement
    © 2010 Royal Society of Chemistry. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal website for access to the definitive, published version.
    Subject
    Medicinal and biomolecular chemistry
    Organic chemistry
    Natural products and bioactive compounds
    Publication URI
    http://hdl.handle.net/10072/35083
    Collection
    • Journal articles

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