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  • Lamellipodia mediate the heterogeneity of central olfactory ensheathing cell interactions

    Author(s)
    Windus, Louisa CE
    Lineburg, Katie E
    Scott, Susan E
    Claxton, Christina
    Mackay-Sim, Alan
    Key, Brian
    St John, James A
    Griffith University Author(s)
    Mackay-Sim, Alan
    St John, James A.
    Ekberg, Jenny A.
    Year published
    2010
    Metadata
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    Abstract
    The growth and guidance of primary olfactory axons are partly attributed to the presence of olfactory ensheathing cells (OECs). However, little is understood about the differences between the subpopulations of OECs and what regulates their interactions. We used OEC-axon assays and determined that axons respond differently to peripheral and central OECs. We then further purified OECs from anatomically distinct regions of the olfactory bulb. Cell behaviour assays revealed that OECs from the olfactory bulb were a functionally heterogeneous population with distinct differences which is consistent with their proposed ...
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    The growth and guidance of primary olfactory axons are partly attributed to the presence of olfactory ensheathing cells (OECs). However, little is understood about the differences between the subpopulations of OECs and what regulates their interactions. We used OEC-axon assays and determined that axons respond differently to peripheral and central OECs. We then further purified OECs from anatomically distinct regions of the olfactory bulb. Cell behaviour assays revealed that OECs from the olfactory bulb were a functionally heterogeneous population with distinct differences which is consistent with their proposed roles in vivo. We found that the heterogeneity was regulated by motile lamellipodial waves along the shaft of the OECs and that inhibition of lamellipodial wave activity via Mek1 abolished the ability of the cells to distinguish between each other. These results demonstrate that OECs from the olfactory bulb are a heterogeneous population that use lamellipodial waves to regulate cell-cell recognition.
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    Journal Title
    Cellular and Molecular Life Sciences
    Volume
    67
    Issue
    10
    DOI
    https://doi.org/10.1007/s00018-010-0280-3
    Subject
    Biochemistry and cell biology
    Zoology
    Clinical sciences
    Cellular nervous system
    Medical biochemistry and metabolomics
    Oncology and carcinogenesis
    Publication URI
    http://hdl.handle.net/10072/35085
    Collection
    • Journal articles

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