dc.contributor.author | Leven, Michael | |
dc.contributor.author | Knaab, Tanja C | |
dc.contributor.author | Held, Jana | |
dc.contributor.author | Duffy, Sandra | |
dc.contributor.author | Meister, Stephan | |
dc.contributor.author | Fischli, Christoph | |
dc.contributor.author | Meitzner, Diane | |
dc.contributor.author | Lehmann, Ursula | |
dc.contributor.author | Lungerich, Beate | |
dc.contributor.author | Kuna, Krystina | |
dc.contributor.author | Stahlke, Petra | |
dc.contributor.author | Delves, Michael | |
dc.contributor.author | Buchholz, Mirko | |
dc.contributor.author | Winzeler, Elizabeth A | |
dc.contributor.author | Avery, Vicky M | |
dc.contributor.author | Mordmueller, Benjamin | |
dc.contributor.author | Wittlin, Sergio | |
dc.contributor.author | Kurz, Thomas | |
dc.date.accessioned | 2018-01-23T01:00:52Z | |
dc.date.available | 2018-01-23T01:00:52Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 0022-2623 | |
dc.identifier.doi | 10.1021/acs.jmedchem.7b00140 | |
dc.identifier.uri | http://hdl.handle.net/10072/351638 | |
dc.description.abstract | Structural optimization of 3-hydroxy-N′-arylidenepropanehydrazonamides provided new analogs with nanomolar to subnanomolar antiplasmodial activity against asexual blood stages of Plasmodium falciparum, excellent parasite selectivity, and nanomolar activity against the earliest forms of gametocyte development. Particularly, derivatives with a 1,3-dihalo-6-trifluoromethylphenanthrene moiety showed outstanding in vivo properties and demonstrated in part curative activity in the Plasmodium berghei mouse model when administered perorally. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | American Chemical Society | |
dc.relation.ispartofpagefrom | 6036 | |
dc.relation.ispartofpageto | 6044 | |
dc.relation.ispartofissue | 14 | |
dc.relation.ispartofjournal | Journal of Medicinal Chemistry | |
dc.relation.ispartofvolume | 60 | |
dc.subject.fieldofresearch | Medicinal and Biomolecular Chemistry not elsewhere classified | |
dc.subject.fieldofresearch | Medicinal and Biomolecular Chemistry | |
dc.subject.fieldofresearch | Organic Chemistry | |
dc.subject.fieldofresearch | Pharmacology and Pharmaceutical Sciences | |
dc.subject.fieldofresearchcode | 030499 | |
dc.subject.fieldofresearchcode | 0304 | |
dc.subject.fieldofresearchcode | 0305 | |
dc.subject.fieldofresearchcode | 1115 | |
dc.title | 3-Hydroxy-N'-arylidenepropanehydrazonamides with Halo-Substituted Phenanthrene Scaffolds Cure P. berghei Infected Mice When Administered Perorally | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Duffy, Sandra | |
gro.griffith.author | Avery, Vicky M. | |