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dc.contributor.authorLawson, Rachael A
dc.contributor.authorYarnall, Alison J
dc.contributor.authorDuncan, Gordon W
dc.contributor.authorBreen, David P
dc.contributor.authorKhoo, Tien K
dc.contributor.authorWilliams-Gray, Caroline H
dc.contributor.authorBarker, Roger A
dc.contributor.authorBurn, David J
dc.date.accessioned2018-01-12T12:31:20Z
dc.date.available2018-01-12T12:31:20Z
dc.date.issued2017
dc.identifier.issn0022-3050
dc.identifier.doi10.1136/jnnp-2016-315099
dc.identifier.urihttp://hdl.handle.net/10072/351647
dc.description.abstractBackground: Mild cognitive impairment (MCI) is common in early Parkinson's disease (PD). We evaluated the stability of PD-MCI over time to determine its clinical utility as a marker of disease. Methods: 212 newly diagnosed participants with PD were recruited into a longitudinal study and reassessed after 18 and 36 months. Participants completed a range of clinical and neuropsychological assessments. PD-MCI was classified using Movement Disorders Society Task Force level I (Montreal Cognitive Assessment <26) and level II (using cut-offs of 1, 1.5 and 2SD) criteria. Results: After 36 months, 75% of participants returned; 8% of patients had developed a dementia all of which were previously PD-MCI. Applying level I criteria, 70% were cognitively stable, 19% cognitively declined and 11% improved over 36 months. Applying level II criteria (1, 1.5 and 2SD), 25% were cognitively stable, 41% cognitively declined, 15% improved and 19% fluctuated over 36 months. 18% of participants reverted to normal cognition from PD-MCI. Discussion: Cognitive impairment in PD is complex, with some individuals' function fluctuating over time and some reverting to normal cognition. PD-MCI level I criteria may have greater clinical convenience, but more comprehensive level II criteria with 2SD cut-offs may offer greater diagnostic certainty.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherBMJ Group
dc.relation.ispartofpagefrom648
dc.relation.ispartofpageto652
dc.relation.ispartofissue8
dc.relation.ispartofjournalJournal of Neurology, Neurosurgery and Psychiatry
dc.relation.ispartofvolume88
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchPsychology
dc.subject.fieldofresearchcode32
dc.subject.fieldofresearchcode52
dc.titleStability of mild cognitive impairment in newly diagnosed Parkinson's disease
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© The Author(s) 2017. This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/
gro.hasfulltextFull Text
gro.griffith.authorKhoo, Tien Kheng


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