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  • Incidence and prevalence of NMOSD in Australia and New Zealand

    Author(s)
    Bukhari, Wajih
    Prain, Kerri M
    Waters, Patrick
    Woodhall, Mark
    O'Gorman, Cullen M
    Clarke, Laura
    Silvestrini, Roger A
    Bundell, Christine S
    Abernethy, David
    Bhuta, Sandeep
    Blum, Stefan
    Boggild, Mike
    Boundy, Karyn
    Brew, Bruce J
    Brown, Matthew
    Brownlee, Wallace J
    Butzkueven, Helmut
    Carroll, William M
    Chen, Celia
    Coulthard, Alan
    Dale, Russell C
    Das, Chandi
    Dear, Keith
    Fabis-Pedrini, Marzena J
    Fulcher, David
    Gillis, David
    Hawke, Simon
    Heard, Robert
    Henderson, Andrew PD
    Heshmat, Saman
    Hodgkinson, Suzanne
    Jimenez-Sanchez, Sofia
    Killpatrick, Trevor
    King, John
    Kneebone, Christopher
    Kornberg, Andrew J
    Lechner-Scott, Jeannette
    Lin, Ming-Wei
    Lynch, Christpher
    Macdonell, Richard
    Mason, Deborah F
    McCombe, Pamela A
    Pender, Michael P
    Pereira, Jennifer A
    Pollard, John D
    Reddel, Stephen W
    Shaw, Cameron
    Spies, Judith
    Stankovich, James
    Sutton, Ian
    Vucic, Steve
    Walsh, Michael
    Wong, Richard C
    Yiu, Eppie M
    Barnett, Michael H
    Kermode, Allan G
    Marriott, Mark P
    Parratt, John DE
    Slee, Mark
    Taylor, Bruce V
    Willoughby, Ernest
    Wilson, Robert J
    Vincent, Angela
    Broadley, Simon A
    Griffith University Author(s)
    Broadley, Simon
    Year published
    2017
    Metadata
    Show full item record
    Abstract
    Objectives: We have undertaken a clinic-based survey of neuromyelitis optica spectrum disorders (NMOSDs) in Australia and New Zealand to establish incidence and prevalence across the region and in populations of differing ancestry. Background: NMOSD is a recently defined demyelinating disease of the central nervous system (CNS). The incidence and prevalence of NMOSD in Australia and New Zealand has not been established. Methods: Centres managing patients with demyelinating disease of the CNS across Australia and New Zealand reported patients with clinical and laboratory features that were suspicious for NMOSD. Testing for ...
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    Objectives: We have undertaken a clinic-based survey of neuromyelitis optica spectrum disorders (NMOSDs) in Australia and New Zealand to establish incidence and prevalence across the region and in populations of differing ancestry. Background: NMOSD is a recently defined demyelinating disease of the central nervous system (CNS). The incidence and prevalence of NMOSD in Australia and New Zealand has not been established. Methods: Centres managing patients with demyelinating disease of the CNS across Australia and New Zealand reported patients with clinical and laboratory features that were suspicious for NMOSD. Testing for aquaporin 4 antibodies was undertaken in all suspected cases. From this group, cases were identified who fulfilled the 2015 Wingerchuk diagnostic criteria for NMOSD. A capture–recapture methodology was used to estimate incidence and prevalence, based on additional laboratory identified cases. Results: NMOSD was confirmed in 81/170 (48%) cases referred. Capture–recapture analysis gave an adjusted incidence estimate of 0.37 (95% CI 0.35 to 0.39) per million per year and a prevalence estimate for NMOSD of 0.70 (95% CI 0.61 to 0.78) per 100 000. NMOSD was three times more common in the Asian population (1.57 (95% CI 1.15 to 1.98) per 100 000) compared with the remainder of the population (0.57 (95% CI 0.50 to 0.65) per 100 000). The latitudinal gradient evident in multiple sclerosis was not seen in NMOSD. Conclusions: NMOSD incidence and prevalence in Australia and New Zealand are comparable with figures from other populations of largely European ancestry. We found NMOSD to be more common in the population with Asian ancestry.
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    Journal Title
    Journal of Neurology, Neurosurgery and Psychiatry
    Volume
    88
    Issue
    8
    DOI
    https://doi.org/10.1136/jnnp-2016-314839
    Subject
    Biomedical and clinical sciences
    Psychology
    Publication URI
    http://hdl.handle.net/10072/351648
    Collection
    • Journal articles

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