dc.contributor.author | McCarthy, LC | |
dc.contributor.author | Hosford, DA | |
dc.contributor.author | Riley, JH | |
dc.contributor.author | Bird, MI | |
dc.contributor.author | White, NJ | |
dc.contributor.author | Hewett, DR | |
dc.contributor.author | Peroutka, SJ | |
dc.contributor.author | Griffiths, LR | |
dc.contributor.author | Boyd, PR | |
dc.contributor.author | Lea, RA | |
dc.contributor.author | Bhatti, SM | |
dc.contributor.author | Hosking, LK | |
dc.contributor.author | Hood, CM | |
dc.contributor.author | Jones, KW | |
dc.contributor.author | Handley, AR | |
dc.contributor.author | Rallan, R | |
dc.contributor.author | Lewis, KF | |
dc.contributor.author | Yeo, AJM | |
dc.contributor.author | Williams, PM | |
dc.contributor.author | Priest, RC | |
dc.contributor.author | Khan, P | |
dc.contributor.author | Donnelly, C | |
dc.contributor.author | Lumsden, SM | |
dc.contributor.author | O'Sullivan, J | |
dc.contributor.author | See, CG | |
dc.contributor.author | Smart, DH | |
dc.contributor.author | Shaw-Hawkins, S | |
dc.contributor.author | Patel, J | |
dc.contributor.author | Langrish, TC | |
dc.contributor.author | Feniuk, W | |
dc.contributor.author | Knowles, RG | |
dc.contributor.author | Thomas, M | |
dc.contributor.author | Libri, V | |
dc.contributor.author | Montgomery, DS | |
dc.contributor.author | Manasco, PK | |
dc.contributor.author | Xu, CF | |
dc.contributor.author | Dykes, C | |
dc.contributor.author | Humphrey, PPA | |
dc.contributor.author | Roses, AD | |
dc.contributor.author | Purvis, IJ | |
dc.contributor.editor | not stated | |
dc.date.accessioned | 2017-05-03T13:33:46Z | |
dc.date.available | 2017-05-03T13:33:46Z | |
dc.date.issued | 2001 | |
dc.identifier.issn | 0888-7543 | |
dc.identifier.doi | 10.1006/geno.2001.6647 | |
dc.identifier.uri | http://hdl.handle.net/10072/3526 | |
dc.description.abstract | We have identified a migraine locus on chromosome 19p13.3/2 using linkage and association analysis. We isolated 48 single-nucleotide polymorphisms within the locus, of which we genotyped 24 in a Caucasian population comprising 827 unrelated cases and 765 controls. Five single-nucleotide polymorphisms within the insulin receptor gene showed significant association with migraine. This association was independently replicated in a case-control population collected separately. We used experiments with insulin receptor RNA and protein to investigate functionality for the migraine-associated single-nucleotide polymorphisms. We suggest possible functions for the insulin receptor in migraine pathogenesis. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Academic Press | |
dc.publisher.place | USA | |
dc.relation.ispartofpagefrom | 135 | |
dc.relation.ispartofpageto | 149 | |
dc.relation.ispartofissue | 3 | |
dc.relation.ispartofjournal | Genomics | |
dc.relation.ispartofvolume | 78 | |
dc.subject.fieldofresearch | Genetics | |
dc.subject.fieldofresearch | Information systems | |
dc.subject.fieldofresearchcode | 3105 | |
dc.subject.fieldofresearchcode | 4609 | |
dc.title | Single-Nucleotide Polymorphism Alleles in the insulin receptor gene re associated with typical migraine. | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.date.issued | 2015-05-04T22:02:45Z | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Griffiths, Lyn | |
gro.griffith.author | Lea, Rodney A. | |