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dc.contributor.authorMcCarthy, LC
dc.contributor.authorHosford, DA
dc.contributor.authorRiley, JH
dc.contributor.authorBird, MI
dc.contributor.authorWhite, NJ
dc.contributor.authorHewett, DR
dc.contributor.authorPeroutka, SJ
dc.contributor.authorGriffiths, LR
dc.contributor.authorBoyd, PR
dc.contributor.authorLea, RA
dc.contributor.authorBhatti, SM
dc.contributor.authorHosking, LK
dc.contributor.authorHood, CM
dc.contributor.authorJones, KW
dc.contributor.authorHandley, AR
dc.contributor.authorRallan, R
dc.contributor.authorLewis, KF
dc.contributor.authorYeo, AJM
dc.contributor.authorWilliams, PM
dc.contributor.authorPriest, RC
dc.contributor.authorKhan, P
dc.contributor.authorDonnelly, C
dc.contributor.authorLumsden, SM
dc.contributor.authorO'Sullivan, J
dc.contributor.authorSee, CG
dc.contributor.authorSmart, DH
dc.contributor.authorShaw-Hawkins, S
dc.contributor.authorPatel, J
dc.contributor.authorLangrish, TC
dc.contributor.authorFeniuk, W
dc.contributor.authorKnowles, RG
dc.contributor.authorThomas, M
dc.contributor.authorLibri, V
dc.contributor.authorMontgomery, DS
dc.contributor.authorManasco, PK
dc.contributor.authorXu, CF
dc.contributor.authorDykes, C
dc.contributor.authorHumphrey, PPA
dc.contributor.authorRoses, AD
dc.contributor.authorPurvis, IJ
dc.contributor.editornot stated
dc.date.accessioned2017-05-03T13:33:46Z
dc.date.available2017-05-03T13:33:46Z
dc.date.issued2001
dc.identifier.issn0888-7543
dc.identifier.doi10.1006/geno.2001.6647
dc.identifier.urihttp://hdl.handle.net/10072/3526
dc.description.abstractWe have identified a migraine locus on chromosome 19p13.3/2 using linkage and association analysis. We isolated 48 single-nucleotide polymorphisms within the locus, of which we genotyped 24 in a Caucasian population comprising 827 unrelated cases and 765 controls. Five single-nucleotide polymorphisms within the insulin receptor gene showed significant association with migraine. This association was independently replicated in a case-control population collected separately. We used experiments with insulin receptor RNA and protein to investigate functionality for the migraine-associated single-nucleotide polymorphisms. We suggest possible functions for the insulin receptor in migraine pathogenesis.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAcademic Press
dc.publisher.placeUSA
dc.relation.ispartofpagefrom135
dc.relation.ispartofpageto149
dc.relation.ispartofissue3
dc.relation.ispartofjournalGenomics
dc.relation.ispartofvolume78
dc.subject.fieldofresearchGenetics
dc.subject.fieldofresearchInformation systems
dc.subject.fieldofresearchcode3105
dc.subject.fieldofresearchcode4609
dc.titleSingle-Nucleotide Polymorphism Alleles in the insulin receptor gene re associated with typical migraine.
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2015-05-04T22:02:45Z
gro.hasfulltextNo Full Text
gro.griffith.authorGriffiths, Lyn
gro.griffith.authorLea, Rodney A.


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