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dc.contributor.authorZulfigar, Bilal
dc.contributor.authorShelper, Todd B
dc.contributor.authorAvery, Vicky M
dc.date.accessioned2017-11-14T22:54:44Z
dc.date.available2017-11-14T22:54:44Z
dc.date.issued2017
dc.identifier.issn1359-6446
dc.identifier.doi10.1016/j.drudis.2017.06.004
dc.identifier.urihttp://hdl.handle.net/10072/352766
dc.description.abstractLeishmaniasis, caused by the trypanosomatid protozoan Leishmania, is endemic in 98 countries worldwide, with morbidity and mortality increasing daily. Despite available drugs, leishmaniasis faces the challenge of emerging resistance and toxicity concerns for current drug regimes. Identification of anti-leishmanial compounds representing new chemistry and novel mechanisms of action is essential to populate the drug discovery pipeline. The in vitro assays currently available have shown poor translational outcomes, with high compound attrition rates. It is therefore imperative that more physiologically relevant assays are developed to identify anti-leishmanial compounds. This review provides an overview of the disease, current treatment options and compares the various technologies and assay formats currently available for leishmanial drug discovery.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofpagefrom1516
dc.relation.ispartofpageto1531
dc.relation.ispartofissue10
dc.relation.ispartofjournalDrug Discovery Today
dc.relation.ispartofvolume22
dc.subject.fieldofresearchPharmacology and Pharmaceutical Sciences not elsewhere classified
dc.subject.fieldofresearchBiochemistry and Cell Biology
dc.subject.fieldofresearchPharmacology and Pharmaceutical Sciences
dc.subject.fieldofresearchcode111599
dc.subject.fieldofresearchcode0601
dc.subject.fieldofresearchcode1115
dc.titleLeishmaniasis drug discovery: Recent progress and challenges in assay development
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Sciences, Griffith Institute for Drug Discovery
gro.hasfulltextNo Full Text
gro.griffith.authorAvery, Vicky M.
gro.griffith.authorShelper, Todd B.
gro.griffith.authorZulfiqar, Bilal


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