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dc.contributor.authorZahl, Per-Henriken_US
dc.contributor.authorDe Leo, Diegoen_US
dc.contributor.authorEkeberg, ÿivinden_US
dc.contributor.authorHjelmeland, Heidien_US
dc.contributor.authorDieserud, Gudrunen_US
dc.date.accessioned2017-05-03T11:47:31Z
dc.date.available2017-05-03T11:47:31Z
dc.date.issued2010en_US
dc.date.modified2011-05-04T09:51:52Z
dc.identifier.issn1471-244Xen_US
dc.identifier.urihttp://hdl.handle.net/10072/35294
dc.description.abstractBackground In the period 1990-2006, strong and almost equivalent increases in sales figures of selective serotonin re-uptake inhibitors (SSRIs) were observed in all Nordic countries. The sales figures of tricyclic antidepressants (TCAs) dropped in Norway and Sweden in the nineties. After 2000, sales figures of TCAs have been almost constant in all Nordic countries. The potentially toxic effect of TCAs in overdose was an important reason for replacing TCAs with SSRIs when treating depression. We studied whether the rapid increase in sales of SSRIs and the corresponding decline in TCAs in the period 1990-98 were associated with a decline in suicide rates. Methods Aggregated suicide rates for the period 1975-2006 in four Nordic countries (Denmark, Finland, Norway and Sweden) were obtained from the national causes-of-death registries. The sales figures of antidepressants were provided from the wholesale registers in each of the Nordic countries. Data were analysed using Fisher's exact test and Pearson's correlation coefficient. Results There was no statistical association (P = 1.0) between the increase of sales figures of SSRIs and the decline in suicide rates. There was no statistical association (P = 1.0) between the decrease in the sale figures of TCAs and change in suicide rates either. Conclusions We found no evidence for the rapid increase in use of SSRIs and the corresponding decline in sales of TCAs being associated with a decline in the suicide rates in the Nordic countries in the period 1990-98. We did not find any inverse relationship between the increase in sales of SSRIs and declining suicide rates in four Nordic countries.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.format.extent343510 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherBioMed Central Ltd.en_US
dc.publisher.placeUnited Kingdomen_US
dc.publisher.urihttp://www.biomedcentral.com/1471-244X/10/62en_AU
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom1en_US
dc.relation.ispartofpageto9en_US
dc.relation.ispartofjournalBMC Psychiatryen_US
dc.relation.ispartofvolume10en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchClinical Sciences not elsewhere classifieden_US
dc.subject.fieldofresearchcode110399en_US
dc.titleThe relationship between sales of SSRI, TCA and suicide rates in the Nordic countriesen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
dcterms.licensehttp://creativecommons.org/licenses/by/2.0en_US
gro.description.notepublicPage numbers are not for citation purposes. Instead, this article has the unique article number of 62.en_AU
gro.rights.copyrightCopyright 2010 De Leo et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_AU
gro.date.issued2010
gro.hasfulltextFull Text


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