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dc.contributor.authorBoyd, Roslyn N
dc.contributor.authorZiviani, Jenny
dc.contributor.authorSakzewski, Leanne
dc.contributor.authorNovak, Iona
dc.contributor.authorBadawi, Nadia
dc.contributor.authorPannek, Kerstin
dc.contributor.authorElliott, Catherine
dc.contributor.authorGreaves, Susan
dc.contributor.authorGuzzetta, Andrea
dc.contributor.authorWhittingham, Koa
dc.contributor.authorValentine, Jane
dc.contributor.authorMorgan, Cathy
dc.contributor.authorWallen, Margaret
dc.contributor.authorEliasson, Ann-Christin
dc.contributor.authorFindlay, Lisa
dc.contributor.authorWare, Robert
dc.contributor.authorFiori, Simona
dc.contributor.authorRose, Stephen
dc.date.accessioned2018-01-23T01:01:16Z
dc.date.available2018-01-23T01:01:16Z
dc.date.issued2017
dc.identifier.issn2044-6055
dc.identifier.doi10.1136/bmjopen-2017-017204
dc.identifier.urihttp://hdl.handle.net/10072/353005
dc.description.abstractObjectives: Congenital hemiplegia is the most common form of cerebral palsy (CP). Children with unilateral CP show signs of upper limb asymmetry by 8 months corrected age (ca) but are frequently not referred to therapy until after 12 months ca. This study compares the efficacy of infant-friendly modified constraint-induced movement therapy (Baby mCIMT) to infant friendly bimanual therapy (Baby BIM) on upper limb, cognitive and neuroplasticity outcomes in a multisite randomised comparison trial. Methods and analysis: 150 infants (75 in each group), aged between 3 and 6 months ca, with asymmetric brain injury and clinical signs of upper extremity asymmetry will be recruited. Children will be randomised centrally to receive equal doses of either Baby mCIMT or Baby BIM. Baby mCIMT comprises restraint of the unimpaired hand using a simple restraint (eg, glove, sock), combined with intensive parent implemented practice focusing on active use of the impaired hand in a play-based context. In contrast, Baby BIM promotes active play requiring both hands in a play-based context. Both interventions will be delivered by parents at home with monthly home visits and interim telecommunication support by study therapists. Assessments will be conducted at study entry; at 6, 12 months ca immediately postintervention (primary outcome) and 24 months ca (retention). The primary outcome will be the Mini-Assisting Hand Assessment. Secondary outcomes include the Bayley Scale for Infant and Toddler Development (cognitive and motor domains) and the Hand Assessment of Infants. A subset of children will undertake MRI scans at 24 months ca to evaluate brain lesion severity and brain (re)organisation after intervention. Ethics and dissemination: Full ethical approvals for this study have been obtained from the relevant sites. The findings will be disseminated in peer-reviewed publications.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherBMJ Publishing Group
dc.relation.ispartofpagefrome017204-1
dc.relation.ispartofpagetoe017204-19
dc.relation.ispartofissue9
dc.relation.ispartofjournalBMJ Open
dc.relation.ispartofvolume7
dc.subject.fieldofresearchClinical Sciences not elsewhere classified
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchPublic Health and Health Services
dc.subject.fieldofresearchOther Medical and Health Sciences
dc.subject.fieldofresearchcode110399
dc.subject.fieldofresearchcode1103
dc.subject.fieldofresearchcode1117
dc.subject.fieldofresearchcode1199
dc.titleREACH: study protocol of a randomised trial of rehabilitation very early in congenital hemiplegia
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by-nc/4.0/
dc.description.versionVersion of Record (VoR)
gro.description.notepublicPage numbers are not for citation purposes. Instead, this article has the unique article number of e017204
gro.rights.copyright© The Author(s) 2017.This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
gro.hasfulltextFull Text
gro.griffith.authorWare, Robert


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