Higher versus lower sodium intake for preterm infants

Abstract

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:

To determine the effects of higher versus lower sodium supplementation in preterm infants. We will undertake three comparisons.

1.Higher (commencing ≥ 2 mmol/kg/day) versus lower (commencing < 2 mmol/kg/day) sodium supplementation in preterm infants less than 7 days of age.

2.Higher (≥ 5 mmol/kg/day) versus lower (< 3mmol/kg/day) or intermediate (≥ 3mmol/kg/day to < 5 mmol/kg/day) sodium supplementation in preterm infants ≥ 7 days of age.

1.Higher (≥ 5 mmol/kg/day) versus lower (< 3mmol/kg/day) sodium supplementation in preterm infants ≥ 7 days of age.

2.Higher (≥ 5 mmol/kg/day) versus intermediate (≥ 3mmol/kg/day to < 5 mmol/kg/day) sodium supplementation in preterm infants ≥ 7 days of age.

3.Intermediate (≥ 3mmol/kg/day to < 5 mmol/kg/day) versus lower (< 3mmol/kg/day) sodium supplementation in preterm infants ≥ 7 days of age.

3.Early and late higher versus lower sodium intake.

1.Higher (commencing ≥ 2 mmol/kg/day) or lower (commencing < 2 mmol/kg/day) sodium supplementation in preterm infants less than 7 days of age, and either:

1.higher (≥ 5 mmol/kg/day) versus lower (< 3mmol/kg/day) sodium supplementation in preterm infants ≥ 7 days of age; or

2.higher (≥ 5 mmol/kg/day) versus intermediate (≥ 3mmol/kg/day to < 5 mmol/kg/day) sodium supplementation in preterm infants ≥ 7 days of age; or

3.intermediate (≥ 3mmol/kg/day to < 5 mmol/kg/day) versus lower (< 3mmol/kg/day) sodium supplementation in preterm infants ≥ 7 days of age.

1.Higher (≥ 5 mmol/kg/day) versus lower (< 3mmol/kg/day) sodium supplementation in preterm infants ≥ 7 days of age.

2.Higher (≥ 5 mmol/kg/day) versus intermediate (≥ 3mmol/kg/day to < 5 mmol/kg/day) sodium supplementation in preterm infants ≥ 7 days of age.

3.Intermediate (≥ 3mmol/kg/day to < 5 mmol/kg/day) versus lower (< 3mmol/kg/day) sodium supplementation in preterm infants ≥ 7 days of age.

1.Higher (commencing ≥ 2 mmol/kg/day) or lower (commencing < 2 mmol/kg/day) sodium supplementation in preterm infants less than 7 days of age, and either:

1.higher (≥ 5 mmol/kg/day) versus lower (< 3mmol/kg/day) sodium supplementation in preterm infants ≥ 7 days of age; or

2.higher (≥ 5 mmol/kg/day) versus intermediate (≥ 3mmol/kg/day to < 5 mmol/kg/day) sodium supplementation in preterm infants ≥ 7 days of age; or

3.intermediate (≥ 3mmol/kg/day to < 5 mmol/kg/day) versus lower (< 3mmol/kg/day) sodium supplementation in preterm infants ≥ 7 days of age.

1.higher (≥ 5 mmol/kg/day) versus lower (< 3mmol/kg/day) sodium supplementation in preterm infants ≥ 7 days of age; or

2.higher (≥ 5 mmol/kg/day) versus intermediate (≥ 3mmol/kg/day to < 5 mmol/kg/day) sodium supplementation in preterm infants ≥ 7 days of age; or

3.intermediate (≥ 3mmol/kg/day to < 5 mmol/kg/day) versus lower (< 3mmol/kg/day) sodium supplementation in preterm infants ≥ 7 days of age.