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dc.contributor.authorGreer, Judith M
dc.contributor.authorBroadley, Simon
dc.contributor.authorPender, Michael P
dc.date.accessioned2017-11-27T01:05:07Z
dc.date.available2017-11-27T01:05:07Z
dc.date.issued2017
dc.identifier.issn1664-3224
dc.identifier.doi10.3389/fimmu.2017.00514
dc.identifier.urihttp://hdl.handle.net/10072/354120
dc.description.abstractSeveral lines of evidence suggest a definite and unique link between CNS demyelinating diseases and autoimmune thyroid disease (AITD). The aim of the current study was to systematically compare the clinical and laboratory features of patients with coexistent AITD and CNS demyelinating disease with those of patients with just CNS demyelinating disease. Forty-four patients with coexisting CNS demyelinating disease and AITD were identified and their clinical and radiological features were recorded. Blood and DNA were collected and tested for HLA type and for the response of T cells and antibodies to a variety of antigens. Patients with multiple sclerosis (MS) without AITD and healthy individuals were included as controls. Patients with coexisting AITD and CNS demyelinating disease were almost exclusively female (43/44) and had prominent spinal cord involvement as the main neurological finding. The HLA molecules carried by individuals with CNS demyelinating disease and AITD differed from both other MS patients and healthy individuals. Furthermore, patients with both CNS disease and AITD showed less T cell reactivity than patients with MS alone to myelin proteolipid protein, but, compared to other groups, showed elevated levels of T cell reactivity to the calcitonin gene-related peptide, which is present in both the CNS and the thyroid, and elevated levels of T cell and antibody to the leucine-rich repeat-containing G-protein coupled receptor 4 (LGR4), a molecule that is expressed in the brainstem and spinal cord, and which is a homolog of the thyroid-stimulating hormone receptor. We suggest that reactivity of autoreactive immune cells in these patients against antigens present in both the thyroid and the spinal cord is a potential mechanism underlying the pattern of lesion development in the CNS in patients with coexisting AITD and MS and might indicate a novel mechanism of disease pathogenesis in these patients.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherFrontiers Research Foundation
dc.relation.ispartofpagefrom514-1
dc.relation.ispartofpageto514-13
dc.relation.ispartofjournalFrontiers in Immunology
dc.relation.ispartofvolume8
dc.subject.fieldofresearchImmunology
dc.subject.fieldofresearchImmunology not elsewhere classified
dc.subject.fieldofresearchMedical microbiology
dc.subject.fieldofresearchcode3204
dc.subject.fieldofresearchcode320499
dc.subject.fieldofresearchcode3207
dc.titleReactivity to novel autoantigens in patients with coexisting central nervous system demyelinating disease and autoimmune thyroid disease
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2017 Greer, Broadley and Pender. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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gro.griffith.authorBroadley, Simon


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