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  • Stem cells and their niche in the adult olfactory mucosa

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    Author(s)
    Mackay-Sim, A
    Griffith University Author(s)
    Mackay-Sim, Alan
    Year published
    2010
    Metadata
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    Abstract
    It is well known that new neurons are produced in the adult brain, in the hippocampus and in the subventricular zone. The neural progenitors formed in the subventricular zone migrate forward and join in neural circuits as interneurons in the olfactory bulb, the target for axons from the olfactory sensory neurons in the nose. These neurons are also continually replaced during adulthood from a stem cell in a neurogenic niche in the olfactory epithelium. The stem cell responsible can regenerate all the cells of the olfactory epithelium if damaged by trauma or toxins. This stem cell, the horizontal basal cell, is in a niche ...
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    It is well known that new neurons are produced in the adult brain, in the hippocampus and in the subventricular zone. The neural progenitors formed in the subventricular zone migrate forward and join in neural circuits as interneurons in the olfactory bulb, the target for axons from the olfactory sensory neurons in the nose. These neurons are also continually replaced during adulthood from a stem cell in a neurogenic niche in the olfactory epithelium. The stem cell responsible can regenerate all the cells of the olfactory epithelium if damaged by trauma or toxins. This stem cell, the horizontal basal cell, is in a niche defined by the extra cellular matrix of the basement membrane as well as the many growth factors expressed by surrounding cells and hormones from nearby vasculature. A multipotent cell has been isolated from the olfactory mucosa that can give rise to cells of endodermal and mesodermal origin as well as the expected neural lineage. Whether this is an additional stem cell or the horizontal basal cell is still an open question.
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    Journal Title
    Archives Italiennes de Biologie
    Volume
    148
    Issue
    2
    Publisher URI
    http://www.architalbiol.org/index.php/aib/article/viewArticle/1143
    Copyright Statement
    © 2010 Universita degli Studi di Pisa. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
    Subject
    Cell development, proliferation and death
    Zoology
    Neurosciences
    Neurology and neuromuscular diseases
    Publication URI
    http://hdl.handle.net/10072/35444
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    • Journal articles

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