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dc.contributor.authorde Souza, Paul L
dc.contributor.authorRussell, Pamela J
dc.contributor.authorKearsley, John H
dc.contributor.authorHowes, Laurence G
dc.date.accessioned2017-05-03T14:18:55Z
dc.date.available2017-05-03T14:18:55Z
dc.date.issued2010
dc.date.modified2010-12-24T02:46:47Z
dc.identifier.issn0029-6643
dc.identifier.doi10.1111/j.1753-4887.2010.00314.x
dc.identifier.urihttp://hdl.handle.net/10072/35449
dc.description.abstractIsoflavones are phytoestrogens that have pleiotropic effects in a wide variety of cancer cell lines. Many of these biological effects involve key components of signal transduction pathways within cancer cells, including prostate cancer cells. Epidemiological studies have raised the hypothesis that isoflavones may play an important role in the prevention and modulation of prostate cancer growth. Since randomized phase III trials of isoflavones in prostate cancer prevention are currently lacking, the best evidence for this concept is presently provided by case control studies. However, in vitro data aremuch more convincing in regard to the activity of a number of isoflavones, and have led to the development of genistein and phenoxodiol in the clinic as potential treatments for cancer. In addition, the potential activity of isoflavones in combination with cytotoxics or radiotherapy warrants further investigation. This review focuses on the clinical pharmacology of isoflavones and its relevance to their development for use in the prevention of prostate cancer, and it evaluates some of the conflicting data in the literature.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherInternational Life Sciences Institute
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom542
dc.relation.ispartofpageto555
dc.relation.ispartofissue9
dc.relation.ispartofjournalNutrition Reviews
dc.relation.ispartofvolume68
dc.rights.retentionY
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchPsychology
dc.subject.fieldofresearchcode32
dc.subject.fieldofresearchcode52
dc.titleClinical pharmacology of isoflavones and its relevance for potential prevention of prostate cancer
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2010
gro.hasfulltextNo Full Text
gro.griffith.authorHowes, Laurence G.


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