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dc.contributor.authorCostalat, Guillaume
dc.contributor.authorLemaitre, Frederic
dc.contributor.authorTobin, Barbara
dc.contributor.authorRenshaw, Gillian
dc.date.accessioned2017-12-04T05:08:57Z
dc.date.available2017-12-04T05:08:57Z
dc.date.issued2018
dc.identifier.issn1520-9512
dc.identifier.doi10.1007/s11325-017-1459-8
dc.identifier.urihttp://hdl.handle.net/10072/355088
dc.description.abstractPurpose: The study aims to investigate the effects of moderate intermittent hypoxia (IH) on key cardio-metabolic risk factors in overweight and obese subjects. Methods: Six subjects were exposed to 10 sessions of moderate IH over 2 weeks (based on SpO2¯¯¯¯¯¯¯¯¯¯¯¯=80%SpO2¯=80%; ~70 min per session). Measures were made of blood glucose (GLU) and lactate (La−); high (HDLc) and low-density lipoproteins (LDLc); triglycerides (TRG), systolic (SBP), and diastolic blood pressure (DBP); and cardiac autonomic indices [root mean square of successive R-R interval differences (RMSSD) and short-term fractal scaling exponent (DFAα1)]. Results: GLU decreased and La− increased following a single IH session (6.21 ± 1.62 vs. 5.32 ± 1.03 mmol L−1; p < 0.05; 1.14 ± 0.21 vs. 1.47 ± 0.22 mmol L−1), but no sustained change after 10 sessions of IH occurred (p > 0.05). Conversely, LDLc (3.00 ± 0.68 vs. 2.51 ± 0.60 mmol L−1; p < 0.05), LDLc/HDLc ratio (2.52 ± 0.66 vs. 2.26 ± 0.70 mmol L−1; p < 0.05), and SBP (118.6 ± 13.3 vs. 109.6 ± 11.3 mmHg; p < 0.05) were all significantly decreased after 10 sessions. Conclusion: A short course of recurrent IH appears to be a safe and effective non-pharmacological method of reducing key cardiovascular risk factors associated with metabolic disorders.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofpagefrom1
dc.relation.ispartofpageto5
dc.relation.ispartofjournalSleep and Breathing
dc.subject.fieldofresearchClinical Sciences not elsewhere classified
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchPsychology
dc.subject.fieldofresearchcode110399
dc.subject.fieldofresearchcode1103
dc.subject.fieldofresearchcode1701
dc.titleIntermittent hypoxia revisited: a promising non-pharmaceutical strategy to reduce cardio-metabolic risk factors?
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorRenshaw, Gillian M.
gro.griffith.authorTobin, Barbara M.


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