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dc.contributor.authorMubaiwa, Tsitsi D
dc.contributor.authorSemchenko, Evgeny A
dc.contributor.authorHartley-Tassell, Lauren E
dc.contributor.authorDay, Christopher J
dc.contributor.authorJennings, Michael P
dc.contributor.authorSeib, Kate L
dc.date.accessioned2017-12-14T04:53:42Z
dc.date.available2017-12-14T04:53:42Z
dc.date.issued2017
dc.identifier.issn2049-632X
dc.identifier.doi10.1093/femspd/ftx063
dc.identifier.urihttp://hdl.handle.net/10072/355568
dc.description.abstractGlycomics is a rapidly growing field that focuses on the structure and function of carbohydrates (glycans) in biological systems. Glycan interactions play a major role in infectious disease, at all stages of colonisation and disease progression. Neisseria meningitidis, the cause of meningococcal sepsis and meningitis, and Neisseria gonorrhoeae, which causes the sexually transmitted infection gonorrhoea, are responsible for significant morbidity and mortality worldwide. Neisseria meningitidis displays a range of surface glycosylations including capsule polysaccharide, lipooligosaccharide and O-linked glycoproteins. While N. gonorrhoeae does not have a capsule, it does express both lipooligosaccharide and O-linked glycoproteins. Neisseria gonorrhoeae also has the ability to scavenge host sialic acids, while several N. meningitidis serogroups can synthesise sialic acid. Surface expressed sialic acid is key in serum resistance and survival in the host. On the host side, the pathogenic Neisseria protein adhesins such as Opc and NHBA bind to host glycans for adherence and colonisation of host cells. Essentially, from both the bacterial and host perspective, glycan interactions are fundamental in colonisation and disease of pathogenic Neisseria. The key aspects of glycobiology of the pathogenic Neisseria are reviewed herein.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherOxford University Press
dc.relation.ispartofpagefromftx063-1
dc.relation.ispartofpagetoftx063-9
dc.relation.ispartofissue5
dc.relation.ispartofjournalPathogens and Disease
dc.relation.ispartofvolume75
dc.relation.urihttp://purl.org/au-research/grants/NHMRC/APP1099278
dc.relation.urihttp://purl.org/au-research/grants/NHMRC/APP1045235
dc.relation.grantIDAPP1099278
dc.relation.grantIDAPP1045235
dc.relation.fundersNHMRC
dc.subject.fieldofresearchPathology (excl. Oral Pathology)
dc.subject.fieldofresearchcode110316
dc.titleThe sweet side of the pathogenic Neisseria: The role of glycan interactions in colonisation and disease
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.description.versionVersion of Record (VoR)
gro.facultyOffice of the Snr Dep Vice Chancellor, Institute for Glycomics
gro.rights.copyright© FEMS 2017. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence, which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorJennings, Michael P.
gro.griffith.authorHartley-Tassell, Lauren E.
gro.griffith.authorDay, Christopher J.
gro.griffith.authorMubaiwa, Tsitsi D.
gro.griffith.authorSemchenko, Evgeny
gro.griffith.authorSeib, Kate


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