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dc.contributor.authorLiu, Annieen_US
dc.contributor.authorMenon, Sarasen_US
dc.contributor.authorColson, Natalieen_US
dc.contributor.authorQuinlan, Sharonen_US
dc.contributor.authorCox, Hannahen_US
dc.contributor.authorPeterson, Madelynen_US
dc.contributor.authorTiang, Thomasen_US
dc.contributor.authorHaupt, Larisaen_US
dc.contributor.authorLea, Rodneyen_US
dc.contributor.authorGriffiths, Lynen_US
dc.date.accessioned2017-05-03T14:47:57Z
dc.date.available2017-05-03T14:47:57Z
dc.date.issued2010en_US
dc.date.modified2011-01-27T06:44:50Z
dc.identifier.issn17560500en_US
dc.identifier.doi10.1186/1756-0500-3-213en_AU
dc.identifier.urihttp://hdl.handle.net/10072/35586
dc.description.abstractBackground: The methylenetetrahydrofolate reductase (MTHFR) gene variant C677T has been implicated as a genetic risk factor in migraine susceptibility, particularly in Migraine with Aura. Migraine, with and without aura (MA and MO) have many diagnostic characteristics in common. It is postulated that migraine symptomatic characteristics might themselves be influenced by MTHFR. Here we analysed the clinical profile, migraine symptoms, triggers and treatments of 267 migraineurs previously genotyped for the MTHFR C677T variant. The chisquare test was used to analyse all potential relationships between genotype and migraine clinical variables. Regression analyses were performed to assess the association of C677T with all migraine clinical variables after adjusting for gender. Findings: The homozygous TT genotype was significantly associated with MA (P < 0.0001) and unilateral head pain (P = 0.002). While the CT genotype was significantly associated with physical activity discomfort (P < 0.001) and stress as a migraine trigger (P = 0.002). Females with the TT genotype were significantly associated with unilateral head pain (P < 0.001) and females with the CT genotype were significantly associated with nausea (P < 0.001), osmophobia (P = 0.002), and the use of natural remedy for migraine treatment (P = 0.003). Conversely, male migraineurs with the TT genotype experienced higher incidences of bilateral head pain (63% vs 34%) and were less likely to use a natural remedy as a migraine treatment compared to female migraineurs (5% vs 20%). Conclusions: MTHFR genotype is associated with specific clinical variables of migraine including unilateral head pain, physical activity discomfort and stress.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.format.extent250324 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherBioMed Central Ltd.en_US
dc.publisher.placeUnited Kingdomen_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom1en_US
dc.relation.ispartofpageto6en_US
dc.relation.ispartofjournalBMC Research Notesen_US
dc.relation.ispartofvolume3en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchMedical and Health Sciences not elsewhere classifieden_US
dc.subject.fieldofresearchcode119999en_US
dc.titleAnalysis of the MTHFR C677T variant with migraine phenotypesen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
dcterms.licensehttp://creativecommons.org/licenses/by/2.0en_US
gro.facultyGriffith Health, School of Medical Scienceen_US
gro.description.notepublicPage numbers are not for citation purposes. Instead, this article has the unique article number of 2010, 3:213.en_AU
gro.rights.copyrightCopyright 2010 Liu et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_AU
gro.date.issued2010
gro.hasfulltextFull Text


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