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  • Bid integrates intrinsic and extrinsic signaling in apoptosis induced by α-tocopheryl succinate in human gastric carcinoma cells

    Author(s)
    Zhao, Yan
    Li, Ruisong
    Xia, Wei
    Neuzil, Jiri
    Lu, Yuxia
    Zhang, Haijin
    Zhao, Xiujuan
    Zhang, Xiaohua
    Sun, Changhao
    Wu, Kun
    Griffith University Author(s)
    Neuzil, Jiri
    Year published
    2010
    Metadata
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    Abstract
    The underlying mechanisms of a-tocopheryl succinate (a-TOS)-mediated apoptosis are not understood in detail, although the redox-silent vitamin E analog is a potent apoptogen and anti-cancer agent. Our previous studies showed the important role of Fas signaling in apoptosis induced by the mitocan. The objective of the present study was to investigate whether apoptosis triggered by a-TOS in gastric carcinomas cells involves both mitochondria- and death receptor-dependent pathways. a-TOS induced apoptosis and mitochondrial permeability transition in a concentration- and time-dependent manner. As a consequence, cytochrome c and ...
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    The underlying mechanisms of a-tocopheryl succinate (a-TOS)-mediated apoptosis are not understood in detail, although the redox-silent vitamin E analog is a potent apoptogen and anti-cancer agent. Our previous studies showed the important role of Fas signaling in apoptosis induced by the mitocan. The objective of the present study was to investigate whether apoptosis triggered by a-TOS in gastric carcinomas cells involves both mitochondria- and death receptor-dependent pathways. a-TOS induced apoptosis and mitochondrial permeability transition in a concentration- and time-dependent manner. As a consequence, cytochrome c and the apoptosis-inducing factor were released and caspases were activated. Bax was translocated from the cytosol to mitochondria and Bid was cleaved into its truncated form, tBid. Knocking down Bid by RNAi and Fas antisense oligodeoxynucleotides resulted in a decreased release and cleavage. The results imply that Bid may serve as a critical integrating factor of the death receptor and mitochondrial pathway in a-TOS-mediated apoptosis.
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    Journal Title
    Cancer Letters
    Volume
    288
    Issue
    1
    DOI
    https://doi.org/10.1016/j.canlet.2009.06.021
    Subject
    Oncology and Carcinogenesis not elsewhere classified
    Oncology and Carcinogenesis
    Publication URI
    http://hdl.handle.net/10072/35589
    Collection
    • Journal articles

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