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dc.contributor.authorZhao, Yan
dc.contributor.authorLi, Ruisong
dc.contributor.authorXia, Wei
dc.contributor.authorNeuzil, Jiri
dc.contributor.authorLu, Yuxia
dc.contributor.authorZhang, Haijin
dc.contributor.authorZhao, Xiujuan
dc.contributor.authorZhang, Xiaohua
dc.contributor.authorSun, Changhao
dc.contributor.authorWu, Kun
dc.date.accessioned2017-05-03T14:48:05Z
dc.date.available2017-05-03T14:48:05Z
dc.date.issued2010
dc.date.modified2011-01-24T05:20:33Z
dc.identifier.issn0304-3835
dc.identifier.doi10.1016/j.canlet.2009.06.021
dc.identifier.urihttp://hdl.handle.net/10072/35589
dc.description.abstractThe underlying mechanisms of a-tocopheryl succinate (a-TOS)-mediated apoptosis are not understood in detail, although the redox-silent vitamin E analog is a potent apoptogen and anti-cancer agent. Our previous studies showed the important role of Fas signaling in apoptosis induced by the mitocan. The objective of the present study was to investigate whether apoptosis triggered by a-TOS in gastric carcinomas cells involves both mitochondria- and death receptor-dependent pathways. a-TOS induced apoptosis and mitochondrial permeability transition in a concentration- and time-dependent manner. As a consequence, cytochrome c and the apoptosis-inducing factor were released and caspases were activated. Bax was translocated from the cytosol to mitochondria and Bid was cleaved into its truncated form, tBid. Knocking down Bid by RNAi and Fas antisense oligodeoxynucleotides resulted in a decreased release and cleavage. The results imply that Bid may serve as a critical integrating factor of the death receptor and mitochondrial pathway in a-TOS-mediated apoptosis.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeIreland
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom42
dc.relation.ispartofpageto49
dc.relation.ispartofissue1
dc.relation.ispartofjournalCancer Letters
dc.relation.ispartofvolume288
dc.rights.retentionY
dc.subject.fieldofresearchOncology and Carcinogenesis not elsewhere classified
dc.subject.fieldofresearchOncology and Carcinogenesis
dc.subject.fieldofresearchcode111299
dc.subject.fieldofresearchcode1112
dc.titleBid integrates intrinsic and extrinsic signaling in apoptosis induced by α-tocopheryl succinate in human gastric carcinoma cells
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2010
gro.hasfulltextNo Full Text
gro.griffith.authorNeuzil, Jiri


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