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dc.contributor.authorAbdal-Hay, Abdalla
dc.contributor.authorMemic, Adnan
dc.contributor.authorHussein, Kamal H
dc.contributor.authorOh, Yi Seul
dc.contributor.authorFouad, Mohamed
dc.contributor.authorAl-Jassir, Fawzi F
dc.contributor.authorWoo, Heung-Myong
dc.contributor.authorMorsi, Yosry
dc.contributor.authorMo, Xiumei
dc.contributor.authorIvanovski, Saso
dc.date.accessioned2018-01-02T02:21:19Z
dc.date.available2018-01-02T02:21:19Z
dc.date.issued2017
dc.identifier.issn0014-3057
dc.identifier.doi10.1016/j.eurpolymj.2017.08.054
dc.identifier.urihttp://hdl.handle.net/10072/356070
dc.description.abstractThree dimensional (3D) constructs for vascular tissue engineering applications require scaffolds with highly porous architectures, high biocompatibility and mechanical stability. In this paper, composite fibrous tubular scaffolds composed of different ratios of poly(epsilon-caprolactone) (PCL) and polyamide-6 (PA-6) were simultaneously deposited layer by layer by employing the air jet spinning (AJS) textile technique. Specifically, we report on the optimal parameters for the fabrication of composite porous scaffolds that allow for precise control over the general scaffold architecture, as well as the physical and mechanical properties of the scaffolds. In vitro cell culture study was performed to investigate the influence of polymer composition and scaffold architecture on the adhesion of EA.hy926 human endothelial cells onto the fabricated scaffolds. The cell culture results indicated that a composite scaffold with low PA-6 fibrous content is the most promising substrate for EA.hy926 adhesion and proliferation. Based on the present findings, these highly porous composite tubular constructs support endothelial cell migration and cellular infiltration, and hence represent promising nano-fibrous scaffolds for vascular tissue engineering.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherPergamon
dc.relation.ispartofpagefrom27
dc.relation.ispartofpageto43
dc.relation.ispartofjournalEuropean Polymer Journal
dc.relation.ispartofvolume96
dc.subject.fieldofresearchMacromolecular and materials chemistry
dc.subject.fieldofresearchMacromolecular and materials chemistry not elsewhere classified
dc.subject.fieldofresearchChemical engineering
dc.subject.fieldofresearchMaterials engineering
dc.subject.fieldofresearchcode3403
dc.subject.fieldofresearchcode340399
dc.subject.fieldofresearchcode4004
dc.subject.fieldofresearchcode4016
dc.titleRapid fabrication of highly porous and biocompatible composite textile tubular scaffold for vascular tissue engineering
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Dentistry and Oral Health
gro.hasfulltextNo Full Text
gro.griffith.authorIvanovski, Saso
gro.griffith.authorAli, Abdalla A.


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