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dc.contributor.authorBerridge, Michael V
dc.contributor.authorNeuzil, Jiri
dc.date.accessioned2018-01-02T06:01:16Z
dc.date.available2018-01-02T06:01:16Z
dc.date.issued2017
dc.identifier.issn1440-1681
dc.identifier.doi10.1111/1440-1681.12764
dc.identifier.urihttp://hdl.handle.net/10072/356125
dc.description.abstractThe view that genes are constrained within somatic cells is challenged by in vitro evidence, and more recently by in vivo studies which demonstrate that mitochondria with their mitochondrial DNA (mtDNA) payload not only can, but do move between cells in tumour models and in mouse models of tissue damage. Using mouse tumour cell models without mtDNA to reflect mtDNA damage, we have shown that these cells grow tumours only after acquiring mtDNA from cells in the local microenvironment resulting in respiration recovery, tumorigenesis and metastasis. Mitochondrial transfer between cells has also been demonstrated following ischaemia-induced injury in the heart and brain and in lung epithelium, and following lung inflammation. In vitro investigations suggest that stem cells may be mitochondrial donors. The ability of mitochondria to move between cells appears to be an evolutionarily-conserved phenomenon, relevant to diseases with compromised mitochondrial function including neurodegenerative, neuromuscular and cardiovascular diseases as well as cancer and ageing.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherWiley-Blackwell Publishing Asia
dc.relation.ispartofpagefrom1
dc.relation.ispartofpageto6
dc.relation.ispartofjournalClinical and Experimental Pharmacology and Physiology
dc.relation.ispartofvolume44
dc.subject.fieldofresearchMedical Physiology not elsewhere classified
dc.subject.fieldofresearchPhysiology
dc.subject.fieldofresearchPharmacology and Pharmaceutical Sciences
dc.subject.fieldofresearchMedical Physiology
dc.subject.fieldofresearchcode111699
dc.subject.fieldofresearchcode0606
dc.subject.fieldofresearchcode1115
dc.subject.fieldofresearchcode1116
dc.titleThe mobility of mitochondria: Intercellular trafficking in health and disease
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.description.notepublicThis publication has been entered into Griffith Research Online as an Advanced Online Version.
gro.hasfulltextNo Full Text
gro.griffith.authorNeuzil, Jiri


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