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dc.contributor.authorSingh, Preetinderen_US
dc.contributor.authorYam, M.en_US
dc.contributor.authorRussell, P.en_US
dc.contributor.authorKhatri, A.en_US
dc.date.accessioned2017-05-03T11:48:06Z
dc.date.available2017-05-03T11:48:06Z
dc.date.issued2010en_US
dc.date.modified2011-01-25T02:19:18Z
dc.identifier.issn03043835en_US
dc.identifier.doi10.1016/j.canlet.2009.11.019en_AU
dc.identifier.urihttp://hdl.handle.net/10072/35614
dc.description.abstractCastrate resistant prostate cancer (CRPC) is essentially incurable. Recently though, chemotherapy demonstrated a survival benefit (~2 months) in the treatment of CRPC. While this was a landmark finding, suboptimal efficacy and systemic toxicities at the therapeutic doses warranted further development. Smart combination therapies, acting through multiple mechanisms to target the heterogeneous cell populations of PC and with potential for reduction in individual dosing, need to be developed. In that, targeted molecular chemotherapy has generated significant interest with the potential for localized treatment to generate systemic efficacy. This can be further enhanced through the use of oncolytic conditionally replicative adenoviruses (CRAds) to deliver molecular chemotherapy. The prospects of chemotherapy and molecular-chemotherapy as single and as components of combination therapies are discussed.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherElsevieren_US
dc.publisher.placeIrelanden_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom1en_US
dc.relation.ispartofpageto14en_US
dc.relation.ispartofissue1en_US
dc.relation.ispartofjournalCancer Lettersen_US
dc.relation.ispartofvolume293en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchOncology and Carcinogenesis not elsewhere classifieden_US
dc.subject.fieldofresearchcode111299en_US
dc.titleMolecular and traditional chemotherapy: A united front against prostate canceren_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyGriffith Health, School of Medical Scienceen_US
gro.date.issued2010
gro.hasfulltextNo Full Text


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